<p>In file <b>C:\xampp\htdocs\eclass\include\action.php</b> on line <b>25</b> : <i>Unable to execute statement:"Table '.\eclass\actions_daily' is marked as crashed and should be repaired", sqlstate:"145", errornum:"HY000", 	statement:"SELECT id, TIME_TO_SEC(TIMEDIFF(NOW(), last_update)) AS diff, module_id                                                FROM actions_daily                                                WHERE user_id = ?                                                AND course_id = ?                                                AND day = DATE(NOW())                                                ORDER BY last_update DESC LIMIT 1", 	elapsed:0.003</i></p><p>In file <b>C:\xampp\htdocs\eclass\include\action.php</b> on line <b>50</b> : <i>Unable to execute statement:"Table '.\eclass\actions_daily' is marked as crashed and should be repaired", sqlstate:"145", errornum:"HY000", 	statement:"SELECT id                                    FROM actions_daily                                    WHERE user_id = ?                                    AND module_id = ?                                    AND course_id = ?                                    AND day = '2024-07-23'", 	elapsed:0.002</i></p><p>In file <b>C:\xampp\htdocs\eclass\include\action.php</b> on line <b>71</b> : <i>Unable to execute statement:"Table '.\eclass\actions_daily' is marked as crashed and should be repaired", sqlstate:"145", errornum:"HY000", 	statement:"INSERT INTO actions_daily SET                    user_id = ?,                    module_id = ?,                    course_id = ?,                    hits = 1,                    duration = 900,                    day = '2024-07-23'                     , last_update = NOW() ", 	elapsed:0.001</i></p>ID   140U_DROME              Reviewed;         261 AA.
AC   P81928; Q9VFM8;
DT   28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2003, sequence version 2.
DT   03-APR-2007, entry version 39.
DE   RPII140-upstream gene protein.
GN   Name=140up; ORFNames=CG9852;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   TISSUE=Embryo;
RX   MEDLINE=91276237; PubMed=1905256; DOI=10.1016/0378-1119(91)90361-E;
RA   Sitzler S., Oldenburg I., Petersen G., Bautz E.K.F.;
RT   "Analysis of the promoter region of the housekeeping gene DmRP140 by
RT   sequence comparison of Drosophila melanogaster and Drosophila
RT   virilis.";
RL   Gene 100:155-162(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   MEDLINE=20196006; PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RX   MEDLINE=22426069; PubMed=12537572;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   MEDLINE=22426066; PubMed=12537569;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA   George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA   Rubin G.M., Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- FUNCTION: Essential for viability.
CC   -!- SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein
CC       (Potential).
DR   EMBL; M62975; AAD40352.2; -; Genomic_DNA.
DR   EMBL; AE014297; AAF55023.1; -; Genomic_DNA.
DR   EMBL; AY058577; AAL13806.1; -; mRNA.
DR   PIR; JQ1024; JQ1024.
DR   UniGene; Dm.10056; -.
DR   Ensembl; CG9852; Drosophila melanogaster.
DR   KEGG; dme:Dmel_CG9852; -.
DR   FlyBase; FBgn0010340; 140up.
DR   BioCyc; DMEL-XXX-02:DMEL-XXX-02-011545-MONOMER; -.
DR   GermOnline; CG9852; Drosophila melanogaster.
DR   GO; GO:0007275; P:multicellular organismal development; IMP:UniProtKB.
DR   InterPro; IPR003397; Tim17_Tim22.
DR   Pfam; PF02466; Tim17; 1.
KW   Complete proteome; Membrane; Transmembrane.
FT   CHAIN         1    261       RPII140-upstream gene protein.
FT                                /FTId=PRO_0000064352.
FT   TRANSMEM     67     87       Potential.
FT   TRANSMEM    131    151       Potential.
FT   TRANSMEM    183    203       Potential.
FT   CONFLICT     64     64       S -> F (in Ref. 1).
SQ   SEQUENCE   261 AA;  29182 MW;  5DB78CF6CFC4435A CRC64;
     MNFLWKGRRF LIAGILPTFE GAADEIVDKE NKTYKAFLAS KPPEETGLER LKQMFTIDEF
     GSISSELNSV YQAGFLGFLI GAIYGGVTQS RVAYMNFMEN NQATAFKSHF DAKKKLQDQF
     TVNFAKGGFK WGWRVGLFTT SYFGIITCMS VYRGKSSIYE YLAAGSITGS LYKVSLGLRG
     MAAGGIIGGF LGGVAGVTSL LLMKASGTSM EEVRYWQYKW RLDRDENIQQ AFKKLTEDEN
     PELFKAHDEK TSEHVSLDTI K
//
ID   14KD_DAUCA              Reviewed;         137 AA.
AC   P14009;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   01-MAY-2007, entry version 43.
DE   14 kDa proline-rich protein DC2.15 precursor.
OS   Daucus carota (Carrot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae;
OC   Daucinae; Daucus.
OX   NCBI_TaxID=4039;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Aleith F., Richter G.;
RT   "Gene expression during induction of somatic embryogenesis in carrot
RT   cell suspensions.";
RL   Planta 183:17-24(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 1-8.
RA   Kaldenhoff R., Holk A., Richter G.;
RL   Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be connected with the initiation of embryogenesis or
CC       with the metabolic changes produced by the removal of auxins.
CC   -!- DEVELOPMENTAL STAGE: Transiently expressed during early
CC       embryogenesis.
CC   -!- INDUCTION: By the removal of auxins.
DR   EMBL; X15436; CAA33476.1; -; mRNA.
DR   EMBL; X75806; CAA53441.1; -; Genomic_DNA.
DR   EMBL; X75807; CAA53442.1; -; Genomic_DNA.
DR   EMBL; X75808; CAA53443.1; -; Genomic_DNA.
DR   EMBL; X75809; CAA53444.1; -; Genomic_DNA.
DR   EMBL; X75810; CAA53445.1; -; Genomic_DNA.
DR   PIR; S35714; S35714.
DR   HSSP; P24337; 1HYP.
DR   InterPro; IPR013770; LPT_helical.
DR   InterPro; IPR003612; LTP/seed_store/tryp_amyl_inhib.
DR   Gene3D; G3DSA:1.10.110.10; LPT_helical; 1.
DR   Pfam; PF00234; Tryp_alpha_amyl; 1.
DR   SMART; SM00499; AAI; 1.
KW   Membrane; Signal; Transmembrane.
FT   SIGNAL        1     25       Potential.
FT   CHAIN        26    137       14 kDa proline-rich protein DC2.15.
FT                                /FTId=PRO_0000020572.
FT   TRANSMEM     88    104       Potential.
FT   COMPBIAS     30     49       Pro-rich.
SQ   SEQUENCE   137 AA;  14392 MW;  CAED1BDB3949F890 CRC64;
     MGSKNSASVA LFFTLNILFF ALVSSTEKCP DPYKPKPKPT PKPTPTPYPS AGKCPRDALK
     LGVCADVLNL VHNVVIGSPP TLPCCSLLEG LVNLEAAVCL CTAIKANILG KNLNLPIALS
     LVLNNCGKQV PNGFECT
//
ID   14KD_RHOSH              Reviewed;         124 AA.
AC   P16536;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 2.
DT   31-OCT-2006, entry version 35.
DE   14 kDa peptide of ubiquinol-cytochrome c2 oxidoreductase complex.
OS   Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Rhodobacter.
OX   NCBI_TaxID=1063;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=91340695; PubMed=1651916;
RA   Usui S., Yu L.;
RT   "Subunit IV (Mr = 14,384) of the cytochrome b-c1 complex from
RT   Rhodobacter sphaeroides. Cloning, DNA sequencing, and ubiquinone
RT   binding domain.";
RL   J. Biol. Chem. 266:15644-15649(1991).
RN   [2]
RP   PROTEIN SEQUENCE OF 61-108.
RX   MEDLINE=90110107; PubMed=2153104;
RA   Purvis D.J., Theiler R., Niederman R.A.;
RT   "Chromatographic and protein chemical analysis of the ubiquinol-
RT   cytochrome c2 oxidoreductase isolated from Rhodobacter sphaeroides.";
RL   J. Biol. Chem. 265:1208-1215(1990).
CC   -!- FUNCTION: Component of the ubiquinol-cytochrome c reductase
CC       complex (complex III or cytochrome b-c1 complex), which is a
CC       respiratory chain that generates an electrochemical potential
CC       coupled to ATP synthesis.
DR   EMBL; M68939; AAA26107.1; -; Genomic_DNA.
DR   PIR; A40794; A40794.
KW   Direct protein sequencing; Electron transport; Inner membrane;
KW   Membrane; Oxidoreductase; Respiratory chain; Transmembrane; Transport.
FT   CHAIN         1    124       14 kDa peptide of ubiquinol-cytochrome c2
FT                                oxidoreductase complex.
FT                                /FTId=PRO_0000064353.
FT   TRANSMEM     85    102       Potential.
SQ   SEQUENCE   124 AA;  14393 MW;  E390C856C1D752F3 CRC64;
     MFSFIDDIPS FEQIKARVRD DLRKHGWEKR WNDSRLVQKS RELLNDEELK IDPATWIWKR
     MPSREEVAAR RQRDFETVWK YRYRLGGFAS GALLALALAG IFSTGNFGGS SDAGNRPSVV
     YPIE
//
ID   1A01_GORGO              Reviewed;         365 AA.
AC   P30375;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 49.
DE   Class I histocompatibility antigen, GOGO-A0101 alpha chain precursor.
OS   Gorilla gorilla gorilla (Lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92078860; PubMed=1744581; DOI=10.1084/jem.174.6.1491;
RA   Lawlor D.A., Warren E., Taylor P., Parham P.;
RT   "Gorilla class I major histocompatibility complex alleles: comparison
RT   to human and chimpanzee class I.";
RL   J. Exp. Med. 174:1491-1509(1991).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X60258; CAA42810.1; -; mRNA.
DR   PIR; JH0534; JH0534.
DR   HSSP; P10315; 1HSB.
DR   SMR; P30375; 25-299.
DR   InterPro; IPR013151; Ig.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    365       Class I histocompatibility antigen, GOGO-
FT                                A0101 alpha chain.
FT                                /FTId=PRO_0000018897.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    297       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   365 AA;  40830 MW;  FB1B14BCD4DF63A8 CRC64;
     MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRV DLGTLRGYYN QSEDGSHTIQ
     RMYGCDVGSD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAEITKRK WEAAHFAEQL
     RAYLEGTCVE WLRRHLENGK ETLQRTDAPK THMTHHAVSD HEAILRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PEPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDVSL
     TACKV
//
ID   1A01_HUMAN              Reviewed;         365 AA.
AC   P30443; O77964; O78171; Q9MYA3; Q9TP25; Q9TQP5;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 67.
DE   HLA class I histocompatibility antigen, A-1 alpha chain precursor (MHC
DE   class I antigen A*1).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0101).
RX   MEDLINE=88234547; PubMed=3375250;
RA   Parham P., Lomen C.E., Lawlor D.A., Ways J.P., Holmes N., Coppin H.L.,
RA   Salter R.D., Wan A.M., Ennis P.D.;
RT   "Nature of polymorphism in HLA-A, -B, and -C molecules.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:4005-4009(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0101).
RX   MEDLINE=89235215; PubMed=2715640;
RA   Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.;
RT   "Diversity and diversification of HLA-A,B,C alleles.";
RL   J. Immunol. 142:3937-3950(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0101).
RA   Warren E.;
RL   Submitted (APR-1989) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*0101).
RX   MEDLINE=91067475; PubMed=2251137; DOI=10.1093/nar/18.22.6701;
RA   Girdlestone J.;
RT   "Nucleotide sequence of an HLA-A1 gene.";
RL   Nucleic Acids Res. 18:6701-6701(1990).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*0101).
RX   MEDLINE=98007773; PubMed=9349617;
RA   Laforet M., Froelich N., Parissiadis A., Pfeiffer B., Schell A.,
RA   Faller B., Woehl-Jaegle M.L., Cazenave J.-P., Tongio M.M.;
RT   "A nucleotide insertion in exon 4 is responsible for the absence of
RT   expression of an HLA-A*01 allele.";
RL   Tissue Antigens 50:347-350(1997).
RN   [6]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0101).
RA   Waller M.J., Robinson J., Marsh S.G.E.;
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE A*0101).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*0102).
RX   MEDLINE=95282145; PubMed=7761977;
RA   Browning M.J., Madrigal J.A., Krausa P., Kowalski H., Allsopp C.E.,
RA   Little A.-M., Turner S., Adams E.J., Arnett K.L., Bodmer W.F.,
RA   Parham P.;
RT   "The HLA-A,B,C genotype of the class I negative cell line Daudi
RT   reveals novel HLA-A and -B alleles.";
RL   Tissue Antigens 45:177-187(1995).
RN   [9]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*0103).
RX   MEDLINE=98101100; PubMed=9438203; DOI=10.1016/S0198-8859(97)00204-8;
RA   Sitha S., Scheltinga S.A., Johnston-Dow L.A., White C.B.,
RA   der van Zwan A.W., Bakema J.E., Rozemuller E.H., van der Tweel J.G.,
RA   Kronink M.N., Tilanus M.G.J.;
RT   "A generic sequencing based typing approach for the identification of
RT   HLA-A diversity.";
RL   Hum. Immunol. 57:120-128(1997).
RN   [10]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*0103).
RC   TISSUE=Blood;
RX   MEDLINE=21100775; PubMed=11182232; DOI=10.1016/S0198-8859(00)00238-X;
RA   Poland G.A., Sohni Y., Domanico M., Kroning C.M., DeGoey S.R.,
RA   Jimale M., Jacobson R.M., Moore S.B.;
RT   "High frequency of HLA-A*0103 allele in a Somali population.";
RL   Hum. Immunol. 62:197-200(2001).
RN   [11]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*0106).
RX   MEDLINE=20309230; PubMed=10852390;
RX   DOI=10.1034/j.1399-0039.2000.550412.x;
RA   Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R.,
RA   Ng J., Hartzman R.J., Hurley C.K.;
RT   "Seventeen more novel HLA-A locus alleles.";
RL   Tissue Antigens 55:369-373(2000).
RN   [12]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*0107).
RA   Tamouza R., Fortier C., Mahfoudh N., Schaeffer V., Poirier J.C.,
RA   Marzais F., Gautreau C., Charron D.;
RT   "A new HLA-A*01 allele.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [13]
RP   SULFATION.
RX   MEDLINE=88088800; PubMed=3121736;
RA   Sant A.J., Zacheis M., Rumbarger T., Giacoletto K.S., Schwartz B.D.;
RT   "Human Ia alpha- and beta-chains are sulfated.";
RL   J. Immunol. 140:155-160(1988).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Sulfated. Polyubiquitinated in a post ER compartment through
CC       interaction with human herpesvirus 8 MIR1 protein. This targets
CC       the protein for rapid degradation via the ubiquitin system (By
CC       similarity).
CC   -!- POLYMORPHISM: The following alleles of A-1 are known: A*0101,
CC       A*0102, A*0103, A*0106 and A*0107. The sequence shown is that of
CC       A*0101.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; M24043; AAA59652.1; -; Genomic_DNA.
DR   EMBL; X55710; CAA39243.1; -; Genomic_DNA.
DR   EMBL; Z93949; CAB07989.1; -; Genomic_DNA.
DR   EMBL; AJ278305; CAB93537.1; -; Genomic_DNA.
DR   EMBL; BC003069; AAH03069.1; -; mRNA.
DR   EMBL; U07161; AAA80569.1; -; mRNA.
DR   EMBL; Y12469; CAA73072.1; -; Genomic_DNA.
DR   EMBL; Y12470; CAA73073.1; -; Genomic_DNA.
DR   EMBL; AF214112; AAF19525.1; -; Genomic_DNA.
DR   EMBL; AF214111; AAF19525.1; JOINED; Genomic_DNA.
DR   EMBL; AF143232; AAD33894.1; -; Genomic_DNA.
DR   EMBL; AF143231; AAD33894.1; JOINED; Genomic_DNA.
DR   EMBL; AF219633; AAF73862.1; -; Genomic_DNA.
DR   EMBL; AF219632; AAF73862.1; JOINED; Genomic_DNA.
DR   PIR; I38518; I38518.
DR   PIR; I61856; I61856.
DR   UniGene; Hs.181244; -.
DR   PDB; 1W72; X-ray; A/D=25-298.
DR   Ensembl; ENSG00000206441; Homo sapiens.
DR   H-InvDB; HIX0005684; -.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   LinkHub; P30443; -.
DR   GO; GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
DR   GO; GO:0032393; F:MHC class I receptor activity; NAS:UniProtKB.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   3D-structure; Glycoprotein; Host-virus interaction; Immune response;
KW   Immunoglobulin domain; Membrane; MHC I; Polymorphism; Signal;
KW   Sulfation; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-1 alpha chain.
FT                                /FTId=PRO_0000018813.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   MOD_RES      83     83       Sulfotyrosine (Potential).
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT      33     33       F -> S (in allele A*0102).
FT                                /FTId=VAR_004332.
FT   VARIANT      41     41       R -> S (in allele A*0102).
FT                                /FTId=VAR_004333.
FT   VARIANT      80     80       G -> R (in allele A*0107).
FT                                /FTId=VAR_016719.
FT   VARIANT      91     91       M -> V (in allele A*0107).
FT                                /FTId=VAR_016720.
FT   VARIANT     100    100       A -> E (in allele A*0107).
FT                                /FTId=VAR_016721.
FT   VARIANT     114    114       D -> A (in allele A*0107).
FT                                /FTId=VAR_016722.
FT   VARIANT     121    121       I -> M (in allele A*0103).
FT                                /FTId=VAR_016723.
FT   VARIANT     180    180       R -> L (in allele A*0106).
FT                                /FTId=VAR_016724.
FT   VARIANT     182    182       V -> A (in allele A*0106).
FT                                /FTId=VAR_016725.
FT   STRAND       27     38
FT   TURN         39     41
FT   STRAND       42     52
FT   STRAND       55     61
FT   STRAND       70     73
FT   HELIX        74     78
FT   HELIX        81    108
FT   STRAND      113    115
FT   STRAND      118    127
FT   STRAND      133    142
FT   STRAND      145    150
FT   STRAND      157    161
FT   HELIX       162    173
FT   HELIX       176    185
FT   HELIX       187    198
FT   HELIX       200    203
FT   STRAND      210    217
FT   STRAND      219    235
FT   STRAND      238    243
FT   STRAND      250    254
FT   STRAND      261    263
FT   STRAND      265    274
FT   HELIX       278    280
FT   STRAND      281    286
FT   STRAND      294    297
SQ   SEQUENCE   365 AA;  40846 MW;  8667AFF3F06C4932 CRC64;
     MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ
     IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAVHAAEQR
     RVYLEGRCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
     SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL
     TACKV
//
ID   1A01_PANTR              Reviewed;         365 AA.
AC   P16209; Q549C1;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   01-MAY-2007, entry version 52.
DE   CHLA class I histocompatibility antigen, A-2 alpha chain precursor.
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=90201944; PubMed=1690682;
RA   Lawlor D.A., Warren E., Ward F.E., Parham P.;
RT   "Comparison of class I MHC alleles in humans and apes.";
RL   Immunol. Rev. 113:147-185(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RX   MEDLINE=20322475; PubMed=10866106; DOI=10.1007/s002510050638;
RA   de Groot N.G., Otting N., Arguello R., Watkins D.I., Doxiadis G.G.,
RA   Madrigal J.A., Bontrop R.E.;
RT   "Major histocompatibility complex class I diversity in a West African
RT   chimpanzee population: implications for HIV research.";
RL   Immunogenetics 51:398-409(2000).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; M30678; AAA87970.1; -; mRNA.
DR   EMBL; AF168394; AAF72775.1; -; mRNA.
DR   PIR; I36961; I36961.
DR   HSSP; P10315; 1HSB.
DR   SMR; P16209; 25-299.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    365       CHLA class I histocompatibility antigen,
FT                                A-2 alpha chain.
FT                                /FTId=PRO_0000018910.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   365 AA;  40849 MW;  FC452786BD038D3E CRC64;
     MAVMPPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDEETRS AKAHSQTDRV DLGTLRGYYN QSEDGSHTIQ
     IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHAAEQR
     RAYLEGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL
     TACKV
//
ID   1A01_PONPY              Reviewed;         365 AA.
AC   P16211;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   01-MAY-2007, entry version 51.
DE   Class I histocompatibility antigen, A-1 alpha chain precursor.
OS   Pongo pygmaeus (Orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=90201944; PubMed=1690682;
RA   Lawlor D.A., Warren E., Ward F.E., Parham P.;
RT   "Comparison of class I MHC alleles in humans and apes.";
RL   Immunol. Rev. 113:147-185(1990).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; M30680; AAA88835.1; -; mRNA.
DR   PIR; I84432; I84432.
DR   HSSP; P10315; 1HSB.
DR   SMR; P16211; 25-299.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    365       Class I histocompatibility antigen, A-1
FT                                alpha chain.
FT                                /FTId=PRO_0000018918.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    297       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   365 AA;  40658 MW;  11A5BC183009CF70 CRC64;
     MAIMAPRTLL LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRTPWMEQEG PEYWDRETRS VKAHAQTNRV DLGTLRGYYN QSDGGSHTIQ
     RMFGCDVGPD GRFLRGYEQH AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAAGAAEQD
     RAYLEGLCVE SLRRYLENGK ETLQRTDAPK THMTHHPVSD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGKEQR YTCHVQHEGL PEPLTLRWEL
     SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRRNSDRK GGSYSQAASN DSAQGSDVSL
     TACKV
//
ID   1A01_SAGOE              Reviewed;         365 AA.
AC   P30515;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 46.
DE   Class I histocompatibility antigen, A alpha chain precursor.
OS   Saguinus oedipus (Cotton-top tamarin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Saguinus.
OX   NCBI_TaxID=9490;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=90111120; PubMed=2104912;
RA   Watkins D.I., Letvin N.L., Hughes A.L., Tedder T.F.;
RT   "Molecular cloning of cDNA that encode MHC class I molecules from a
RT   New World primate (Saguinus oedipus). Natural selection acts at
RT   positions that may affect peptide presentation to T cells.";
RL   J. Immunol. 144:1136-1143(1990).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; M33475; AAA36951.1; -; mRNA.
DR   PIR; I56053; I56053.
DR   HSSP; Q29961; 1HSA.
DR   SMR; P30515; 25-299.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    365       Class I histocompatibility antigen, A
FT                                alpha chain.
FT                                /FTId=PRO_0000018920.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    297       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   365 AA;  40973 MW;  B34B24FB6848E373 CRC64;
     MTVMAPRTLL LLLSGALVLT ETWAGSHSMR YFETSVSRPG RGEPRYISVG YVDDTQFVRF
     DSDAASPRME PRAPWMEQEG PEYWEEETRK GKADAQTFRV DLQTLLGYYN QSEAGSHTIQ
     WMYGCDLGPD GRLLRGYDQH AYDGKDYIAL NEDLRSWTAT DVAAQITQRK WEAANEAERT
     RAYLEGTCVE WLHRYLENGK ETLQRAEPPK THVTHHPVSD HEATLRCWAL GFYPAEITVT
     WQRDGEDQTQ DMELVETRPA GDGTFQKWAA VVVLSGEEQR YTCHVQHEGL PEPLTLRWEP
     PSQPTIPIMG IVAILAILGV VVTGAVVAAV MWRKKSSDKK GGSYSQAARS DSAQGSDVSL
     TACKV
//
ID   1A02_GORGO              Reviewed;         365 AA.
AC   P30376;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 47.
DE   Class I histocompatibility antigen, GOGO-A0201 alpha chain precursor.
OS   Gorilla gorilla gorilla (Lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92078860; PubMed=1744581; DOI=10.1084/jem.174.6.1491;
RA   Lawlor D.A., Warren E., Taylor P., Parham P.;
RT   "Gorilla class I major histocompatibility complex alleles: comparison
RT   to human and chimpanzee class I.";
RL   J. Exp. Med. 174:1491-1509(1991).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X60259; CAA42811.1; -; mRNA.
DR   PIR; JH0535; JH0535.
DR   HSSP; P10315; 1HSB.
DR   SMR; P30376; 25-300.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    365       Class I histocompatibility antigen, GOGO-
FT                                A0201 alpha chain.
FT                                /FTId=PRO_0000018898.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   365 AA;  40896 MW;  09E0E5FCD8E58507 CRC64;
     MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEE PEYWDGETRK VKAHSQTDRV NLGTLRGYYN QSEAGSHTIQ
     KMYGCDVGSD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAEITKRK WEAAHFAEQL
     RAYLEGECVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEAILRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHESL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VIAGAVIAAV RWRRKSSDRK GGSYSQAASS DSAQGSDVSL
     TACKV
//
ID   1A02_HUMAN              Reviewed;         365 AA.
AC   P01892; O19619; P06338; P10313; P30444; P30445; P30446; P30514;
AC   Q29680; Q29837; Q29899; Q95352; Q95380; Q9TPX8; Q9TPX9; Q9TPY0;
AC   Q9TQH5; Q9TQI3;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   01-MAY-2007, entry version 87.
DE   HLA class I histocompatibility antigen, A-2 alpha chain precursor (MHC
DE   class I antigen A*2).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*0201).
RX   MEDLINE=85132727; PubMed=2982951;
RA   Koller B.H., Orr H.T.;
RT   "Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-
RT   A alleles at the nucleotide level.";
RL   J. Immunol. 134:2727-2733(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0201).
RX   MEDLINE=89122144; PubMed=2914713;
RA   Cianetti L., Testa U., Scotto L., la Valle R., Simeone A., Boccoli G.,
RA   Giannella G., Peschle C., Boncinelli E.;
RT   "Three new class I HLA alleles: structure of mRNAs and alternative
RT   mechanisms of processing.";
RL   Immunogenetics 29:80-91(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0201).
RX   MEDLINE=90207291; PubMed=2320591;
RA   Ennis P.D., Zemmour J., Salter R.D., Parham P.;
RT   "Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction:
RT   frequency and nature of errors produced in amplification.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 91-365.
RX   MEDLINE=86033791; PubMed=3863816;
RA   Davidson W.F., Kress M., Khoury G., Jay G.;
RT   "Comparison of HLA class I gene sequences. Derivation of locus-
RT   specific oligonucleotide probes specific for HLA-A, HLA-B, and HLA-C
RT   genes.";
RL   J. Biol. Chem. 260:13414-13423(1985).
RN   [5]
RP   NUCLEOTIDE SEQUENCE (ALLELES A*0201; A*0211 AND A*0212).
RX   MEDLINE=92269955; PubMed=1317015; DOI=10.1038/357326a0;
RA   Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J.,
RA   Williams R.C., Luz R., Petzl-Erler M.L., Parham P.;
RT   "Unusual HLA-B alleles in two tribes of Brazilian Indians.";
RL   Nature 357:326-329(1992).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 39-365 (ALLELE A*0201).
RX   MEDLINE=85230571; PubMed=3874058;
RA   Krangel M.S.;
RT   "Unusual RNA splicing generates a secreted form of HLA-A2 in a
RT   mutagenized B lymphoblastoid cell line.";
RL   EMBO J. 4:1205-1210(1985).
RN   [7]
RP   PROTEIN SEQUENCE OF 25-295 (A*0201).
RX   MEDLINE=80056745; PubMed=92029;
RA   Orr H.T., Lopez de Castro J.A., Parham P., Ploegh H.L.,
RA   Strominger J.L.;
RT   "Comparison of amino acid sequences of two human histocompatibility
RT   antigens, HLA-A2 and HLA-B7: location of putative alloantigenic
RT   sites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 76:4395-4399(1979).
RN   [8]
RP   SEQUENCE REVISION (A*0201).
RX   MEDLINE=82247941; PubMed=6179086;
RA   Lopez de Castro J.A., Strominger J.L., Strong D.M., Orr H.T.;
RT   "Structure of crossreactive human histocompatibility antigens HLA-A28
RT   and HLA-A2: possible implications for the generation of HLA
RT   polymorphism.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:3813-3817(1982).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*0201).
RC   TISSUE=Blood;
RX   MEDLINE=95137784; PubMed=7836067; DOI=10.1016/0198-8859(94)90087-6;
RA   Balas A., Garcia-Sanchez F., Gomez-Reino F., Vicario J.L.;
RT   "HLA class I allele (HLA-A2) expression defect associated with a
RT   mutation in its enhancer B inverted CAT box in two families.";
RL   Hum. Immunol. 41:69-73(1994).
RN   [10]
RP   SEQUENCE REVISION.
RA   Balas A.;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [11]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0201).
RA   Cox S.T.;
RT   "Confirmation of HLA-A*0201.";
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [12]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELES A*0202 AND
RP   A*0203).
RX   MEDLINE=87306734; PubMed=3497874;
RA   Mattson D.H., Handy D.E., Bradley D.A., Coligan J.E., Cowan E.P.,
RA   Biddison W.E.;
RT   "DNA sequences of the genes that encode the CTL-defined HLA-A2
RT   variants M7 and DK1.";
RL   Immunogenetics 26:190-192(1987).
RN   [13]
RP   NUCLEOTIDE SEQUENCE (ALLELES A*0203 AND A*0205).
RX   MEDLINE=87252273; PubMed=3496393;
RA   Holmes N., Ennis P., Wan A.M., Denney D.W., Parham P.;
RT   "Multiple genetic mechanisms have contributed to the generation of the
RT   HLA-A2/A28 family of class I MHC molecules.";
RL   J. Immunol. 139:936-941(1987).
RN   [14]
RP   NUCLEOTIDE SEQUENCE (ALLELES A*0203 AND A*0205).
RA   Domena J.D.;
RL   Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
RN   [15]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 9-365 (ALLELE A*0204).
RX   MEDLINE=92039809; PubMed=1937577; DOI=10.1007/BF00211991;
RA   Castano A.R., Lopez de Castro J.A.;
RT   "Structure of the HLA-A*0204 antigen, found in South American Indians.
RT   Spatial clustering of HLA-A2 subtype polymorphism.";
RL   Immunogenetics 34:281-285(1991).
RN   [16]
RP   NUCLEOTIDE SEQUENCE OF 9-365 (ALLELE A*0204).
RX   MEDLINE=92269956; PubMed=1589035; DOI=10.1038/357329a0;
RA   Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L.,
RA   Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H.,
RA   Troup G.M., Hughes A.L., Letvin N.L.;
RT   "New recombinant HLA-B alleles in a tribe of South American
RT   Amerindians indicate rapid evolution of MHC class I loci.";
RL   Nature 357:329-333(1992).
RN   [17]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0206).
RX   MEDLINE=89235215; PubMed=2715640;
RA   Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.;
RT   "Diversity and diversification of HLA-A,B,C alleles.";
RL   J. Immunol. 142:3937-3950(1989).
RN   [18]
RP   PARTIAL PROTEIN SEQUENCE (A*0206).
RX   MEDLINE=86305811; PubMed=3489037;
RA   Ezquerra A., Domenech N., van der Poel J., Strominger J.L., Vega M.A.,
RA   Lopez de Castro J.A.;
RT   "Molecular analysis of an HLA-A2 functional variant CLA defined by
RT   cytolytic T lymphocytes.";
RL   J. Immunol. 137:1642-1649(1986).
RN   [19]
RP   PARTIAL PROTEIN SEQUENCE (A*0207).
RX   MEDLINE=88113844; PubMed=2448239;
RA   Domenech N., Ezquerra A., Castano R., Lopez de Castro J.A.;
RT   "Structural analysis of HLA-A2.4 functional variant KNE. Implications
RT   for the mapping of HLA-A2-specific T-cell epitopes.";
RL   Immunogenetics 27:196-202(1988).
RN   [20]
RP   PARTIAL PROTEIN SEQUENCE (A*0208).
RX   MEDLINE=88314183; PubMed=2457548;
RA   Domenech N., Castano R., Goulmy E., Lopez de Castro J.A.;
RT   "Molecular analysis of HLA-A2.4 functional variant KLO: close
RT   structural and evolutionary relatedness to the HLA-A2.2 subtype.";
RL   Immunogenetics 28:143-152(1988).
RN   [21]
RP   PARTIAL PROTEIN SEQUENCE (A*0209).
RX   MEDLINE=88186100; PubMed=3258580;
RA   Castano R., Ezquerra A., Domenech N., Lopez de Castro J.A.;
RT   "An HLA-A2 population variant with structural polymorphism in the
RT   alpha 3 region.";
RL   Immunogenetics 27:345-355(1988).
RN   [22]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0210).
RX   MEDLINE=89122133; PubMed=2783680;
RA   Epstein H., Kennedy L., Holmes N.;
RT   "An Oriental HLA-A2 subtype is closely related to a subset of
RT   Caucasoid HLA-A2 alleles.";
RL   Immunogenetics 29:112-116(1989).
RN   [23]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 9-365 (ALLELE A*0211).
RX   MEDLINE=92218010; PubMed=1559719; DOI=10.1007/BF00189898;
RA   Castano A.R., Lopez de Castro J.A.;
RT   "Structure of the HLA-A*0211 (A2.5) subtype: further evidence for
RT   selection-driven diversification of HLA-A2 antigens.";
RL   Immunogenetics 35:344-346(1992).
RN   [24]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*0213).
RX   MEDLINE=94222455; PubMed=8168863; DOI=10.1007/BF00189243;
RA   Barber D.F., Fernandez J.M., Lopez de Castro J.A.;
RT   "Primary structure of a new HLA-A2 subtype: HLA-A*0213.";
RL   Immunogenetics 39:378-378(1994).
RN   [25]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*0216).
RX   MEDLINE=95278976; PubMed=7759139;
RA   Barouch D., Krausa P., Bodmer J., Browning M.J., McMichael A.J.;
RT   "Identification of a novel HLA-A2 subtype, HLA-A*0216.";
RL   Immunogenetics 41:388-388(1995).
RN   [26]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*0217).
RC   TISSUE=Blood;
RX   MEDLINE=95381236; PubMed=7652742;
RA   Selvakumar A., Granja C.B., Salazar M., Alosco S.M., Yunis E.J.,
RA   Dupont B.;
RT   "A novel subtype of A2 (A*0217) isolated from the South American
RT   Indian B-cell line AMALA.";
RL   Tissue Antigens 45:343-347(1995).
RN   [27]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0218).
RC   TISSUE=Blood;
RA   Kashiwase K., Tokunaga K., Ishikawa Y., Oohashi H., Hashimoto M.,
RA   Akaza T., Tadokoro K., Juji T.;
RT   "A new A2 sequence HLA-A2K from Japanese.";
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN   [28]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*0220).
RC   TISSUE=Blood;
RX   MEDLINE=97161038; PubMed=9008310;
RA   Fleischhauer K., Zino E., Mazzi B., Severini G.M., Benazzi E.,
RA   Bordignon C.;
RT   "HLA-A*02 subtype distribution in Caucasians from northern Italy:
RT   identification of A*0220.";
RL   Tissue Antigens 48:673-679(1996).
RN   [29]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0221).
RC   TISSUE=Blood;
RA   Szmania S., Baxter-Lowe L.A.;
RT   "Nucleotide sequence of a novel HLA-A2 gene.";
RL   Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [30]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*0231).
RX   MEDLINE=20156437; PubMed=10689125; DOI=10.1016/S0198-8859(99)00155-X;
RA   Ellis J.M., Henson V., Slack R., Ng J., Hartzman R.J.,
RA   Katovich Hurley C.;
RT   "Frequencies of HLA-A2 alleles in five U.S. population groups.
RT   Predominance Of A*02011 and identification of HLA-A*0231.";
RL   Hum. Immunol. 61:334-340(2000).
RN   [31]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELE A*0234).
RX   MEDLINE=20208581; PubMed=10746792;
RX   DOI=10.1034/j.1399-0039.2000.550212.x;
RA   Moses J.H., Greville W.D., Downes J., McClenahan W., Kennedy A.,
RA   Dunckley H.;
RT   "A new HLA-A*02 allele, A*0234, detected by polymerase chain reaction
RT   using sequence-specific primers (PCR-SSP).";
RL   Tissue Antigens 55:175-177(2000).
RN   [32]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*0235; A*0236 AND A*0237).
RX   MEDLINE=20309230; PubMed=10852390;
RX   DOI=10.1034/j.1399-0039.2000.550412.x;
RA   Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R.,
RA   Ng J., Hartzman R.J., Hurley C.K.;
RT   "Seventeen more novel HLA-A locus alleles.";
RL   Tissue Antigens 55:369-373(2000).
RN   [33]
RP   X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF A*0201.
RX   MEDLINE=88014204; PubMed=3309677; DOI=10.1038/329506a0;
RA   Bjorkman P.J., Saper M.A., Samraoui B., Bennett W.S., Strominger J.L.,
RA   Wiley D.C.;
RT   "Structure of the human class I histocompatibility antigen, HLA-A2.";
RL   Nature 329:506-512(1987).
RN   [34]
RP   INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I.
RX   PubMed=11390610; DOI=10.1128/JVI.75.13.6086-6094.2001;
RA   Johnson J.M., Nicot C., Fullen J., Ciminale V., Casareto L.,
RA   Mulloy J.C., Jacobson S., Franchini G.;
RT   "Free major histocompatibility complex class I heavy chain is
RT   preferentially targeted for degradation by human T-cell
RT   leukemia/lymphotropic virus type 1 p12(I) protein.";
RL   J. Virol. 75:6086-6094(2001).
RN   [35]
RP   INTERACTION WITH HUMAN HERPESVIRUS 8 MIR1 PROTEIN.
RX   PubMed=12006494; DOI=10.1093/emboj/21.10.2418;
RA   Hewitt E.W., Duncan L., Mufti D., Baker J., Stevenson P.G.,
RA   Lehner P.J.;
RT   "Ubiquitylation of MHC class I by the K3 viral protein signals
RT   internalization and TSG101-dependent degradation.";
RL   EMBO J. 21:2418-2429(2002).
RN   [36]
RP   X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF A*0201.
RX   MEDLINE=91245570; PubMed=2038058; DOI=10.1016/0022-2836(91)90567-P;
RA   Saper M.A., Bjorkman P.J., Wiley D.C.;
RT   "Refined structure of the human histocompatibility antigen HLA-A2 at
RT   2.6-A resolution.";
RL   J. Mol. Biol. 219:277-319(1991).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein.
CC       Interacts with HTLV-1 accessory protein p12I.
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment through
CC       interaction with human herpesvirus 8 MIR1 protein. This targets
CC       the protein for rapid degradation via the ubiquitin system.
CC   -!- POLYMORPHISM: The following alleles of A-2 are known: A*0201,
CC       A*0202, A*0203, A*0204, A*0205, A*0206 (A2.4A), A*0207, A*0208,
CC       A*0209, A*0210, A*0211 (A2.5), A*0212, A*0213 (A*02SLU), A*0216,
CC       A*0217, A*0218 (A2K), A*0219, A*0220, A*0221, A*0231, A*0234
CC       (A*AAT), A*0235, A*0236 and A*0237. The sequence shown is that of
CC       A*0201.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
CC   -!- CAUTION: Ref.6 and Ref.7 sequences differ from that shown
CC       extensively.
DR   EMBL; K02883; AAA98727.1; -; Genomic_DNA.
DR   EMBL; M84379; AAA59606.1; -; mRNA.
DR   EMBL; X02457; CAA26297.1; -; mRNA.
DR   EMBL; M11887; AAA52656.1; -; mRNA.
DR   EMBL; M19670; AAA03683.2; -; Genomic_DNA.
DR   EMBL; M17690; AAB02120.1; -; Genomic_DNA.
DR   EMBL; U03863; AAA03604.1; -; Unassigned_DNA.
DR   EMBL; M86404; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; X57954; CAA41022.1; ALT_SEQ; mRNA.
DR   EMBL; U02935; AAA76608.2; -; Genomic_DNA.
DR   EMBL; AJ555412; CAD87771.1; -; Genomic_DNA.
DR   EMBL; U03862; AAA03603.1; -; Unassigned_DNA.
DR   EMBL; M24042; AAA59653.1; -; mRNA.
DR   EMBL; Z23071; CAA80612.1; -; mRNA.
DR   EMBL; M84377; AAA59603.1; -; mRNA.
DR   EMBL; X60764; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; M84378; AAA59604.1; -; mRNA.
DR   EMBL; Z27120; CAA81644.1; -; mRNA.
DR   EMBL; Z46633; CAA86602.1; -; mRNA.
DR   EMBL; U18930; AAA87076.1; -; mRNA.
DR   EMBL; D83515; BAA11935.1; -; mRNA.
DR   EMBL; X96724; CAA65501.1; -; mRNA.
DR   EMBL; U56825; AAB17465.1; -; mRNA.
DR   EMBL; AF113924; AAD23437.1; -; Genomic_DNA.
DR   EMBL; AF113923; AAD23437.1; JOINED; Genomic_DNA.
DR   EMBL; AF129431; AAD30272.1; -; Genomic_DNA.
DR   EMBL; AF129429; AAD30272.1; JOINED; Genomic_DNA.
DR   EMBL; AF129430; AAD30272.1; JOINED; Genomic_DNA.
DR   EMBL; AF157311; AAD45690.1; -; Genomic_DNA.
DR   EMBL; AF157310; AAD45690.1; JOINED; Genomic_DNA.
DR   EMBL; AF157309; AAD45689.1; -; Genomic_DNA.
DR   EMBL; AF157308; AAD45689.1; JOINED; Genomic_DNA.
DR   EMBL; AF157564; AAD45324.1; -; Genomic_DNA.
DR   EMBL; AF157563; AAD45324.1; JOINED; Genomic_DNA.
DR   PIR; B24512; HLHU10.
DR   PIR; I38418; I38418.
DR   PIR; I38442; I38442.
DR   PIR; I61857; I61857.
DR   UniGene; Hs.181244; -.
DR   PDB; 1AKJ; X-ray; A=25-300.
DR   PDB; 1AO7; X-ray; A=25-299.
DR   PDB; 1AQD; X-ray; C/F/I/L=127-141.
DR   PDB; 1B0G; X-ray; A/D=25-299.
DR   PDB; 1B0R; X-ray; A=25-299.
DR   PDB; 1BD2; X-ray; A=25-299.
DR   PDB; 1DUY; X-ray; A/D=25-299.
DR   PDB; 1DUZ; X-ray; A/D=25-299.
DR   PDB; 1EEY; X-ray; A/D=25-299.
DR   PDB; 1EEZ; X-ray; A/D=25-299.
DR   PDB; 1HHG; X-ray; A/D=25-299.
DR   PDB; 1HHH; X-ray; A=25-299.
DR   PDB; 1HHI; X-ray; A/D=25-299.
DR   PDB; 1HHJ; X-ray; A/D=25-299.
DR   PDB; 1HHK; X-ray; A/D=25-299.
DR   PDB; 1HLA; X-ray; A=25-294.
DR   PDB; 1I1F; X-ray; A/D=25-299.
DR   PDB; 1I1Y; X-ray; A/D=25-299.
DR   PDB; 1I4F; X-ray; A=25-299.
DR   PDB; 1I7R; X-ray; A/D=25-299.
DR   PDB; 1I7T; X-ray; A/D=25-299.
DR   PDB; 1I7U; X-ray; A/D=25-299.
DR   PDB; 1IM3; X-ray; A/E/I/M=25-299.
DR   PDB; 1JF1; X-ray; A=25-299.
DR   PDB; 1JHT; X-ray; A=25-299.
DR   PDB; 1LP9; X-ray; A/H=25-299.
DR   PDB; 1OGA; X-ray; A=25-300.
DR   PDB; 1P7Q; X-ray; A=25-300.
DR   PDB; 1QEW; X-ray; A=25-299.
DR   PDB; 1QR1; X-ray; A/D=25-299.
DR   PDB; 1QRN; X-ray; A=25-298.
DR   PDB; 1QSE; X-ray; A=25-298.
DR   PDB; 1QSF; X-ray; A=25-298.
DR   PDB; 1S9W; X-ray; A=25-298.
DR   PDB; 1S9X; X-ray; A=25-298.
DR   PDB; 1S9Y; X-ray; A=25-298.
DR   PDB; 1TVB; X-ray; A/D=25-299.
DR   PDB; 1TVH; X-ray; A/D=25-299.
DR   PDB; 1UR7; Model; A=25-299.
DR   PDB; 2AV1; X-ray; A/D=25-299.
DR   PDB; 2AV7; X-ray; A/D=25-299.
DR   PDB; 2BNQ; X-ray; A=25-300.
DR   PDB; 2BNR; X-ray; A=25-300.
DR   PDB; 2BSU; X-ray; A/D=25-300.
DR   PDB; 2BSV; X-ray; A/D=25-300.
DR   PDB; 2C7U; X-ray; A/D=25-300.
DR   PDB; 2CLR; X-ray; A/D=25-299.
DR   PDB; 2F53; X-ray; A=25-299.
DR   PDB; 2F54; X-ray; A/F=25-298.
DR   PDB; 3HLA; X-ray; A=25-294.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   LinkHub; P01892; -.
DR   ArrayExpress; P01892; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   3D-structure; Direct protein sequencing; Glycoprotein;
KW   Host-virus interaction; Immune response; Membrane; MHC I;
KW   Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-2 alpha chain.
FT                                /FTId=PRO_0000018814.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...).
FT   DISULFID    125    188
FT   DISULFID    227    283
FT   VARIANT      33     33       F -> Y (in allele A*0205, allele A*0206,
FT                                allele A*0208, allele A*0210 and allele
FT                                A*0221).
FT                                /FTId=VAR_004334.
FT   VARIANT      54     54       D -> N (in allele A*0221).
FT                                /FTId=VAR_004335.
FT   VARIANT      65     65       A -> G (in allele A*0231).
FT                                /FTId=VAR_016726.
FT   VARIANT      67     67       Q -> R (in allele A*0202, allele A*0205
FT                                and allele A*0208).
FT                                /FTId=VAR_004336.
FT   VARIANT      90     90       K -> N (in allele A*0208 and allele
FT                                A*0220).
FT                                /FTId=VAR_004337.
FT   VARIANT      94     94       H -> Q (in allele A*0234 and allele
FT                                A*0235).
FT                                /FTId=VAR_016727.
FT   VARIANT      97     97       T -> I (in allele A*0211).
FT                                /FTId=VAR_004338.
FT   VARIANT      98     98       H -> D (in allele A*0211 and allele
FT                                A*0235).
FT                                /FTId=VAR_016728.
FT   VARIANT     119    119       V -> L (in allele A*0202, allele A*0205,
FT                                allele A*0208 and allele A*0217).
FT                                /FTId=VAR_004339.
FT   VARIANT     121    121       R -> M (in allele A*0204 and allele
FT                                A*0217).
FT                                /FTId=VAR_004340.
FT   VARIANT     123    123       Y -> C (in allele A*0207 and allele
FT                                A*0218).
FT                                /FTId=VAR_004341.
FT   VARIANT     123    123       Y -> F (in allele A*0210 and allele
FT                                A*0217).
FT                                /FTId=VAR_004342.
FT   VARIANT     131    131       W -> G (in allele A*0210).
FT                                /FTId=VAR_004343.
FT   VARIANT     162    162       M -> K (in allele A*0218).
FT                                /FTId=VAR_004344.
FT   VARIANT     173    173       A -> T (in allele A*0203).
FT                                /FTId=VAR_004345.
FT   VARIANT     176    176       V -> E (in allele A*0203 and allele
FT                                A*0213).
FT                                /FTId=VAR_004346.
FT   VARIANT     180    180       L -> Q (in allele A*0212, allele A*0213
FT                                and allele A*0237).
FT                                /FTId=VAR_004348.
FT   VARIANT     180    180       L -> W (in allele A*0202, allele A*0203,
FT                                allele A*0205 and allele A*0208).
FT                                /FTId=VAR_004347.
FT   VARIANT     187    187       T -> E (in allele A*0216; requires 2
FT                                nucleotide substitutions).
FT                                /FTId=VAR_004349.
FT   VARIANT     190    190       E -> D (in allele A*0236 and allele
FT                                A*0237).
FT                                /FTId=VAR_016729.
FT   VARIANT     191    191       W -> G (in allele A*0236 and allele
FT                                A*0237).
FT                                /FTId=VAR_016730.
FT   VARIANT     260    260       A -> E (in allele A*0209).
FT                                /FTId=VAR_004350.
FT   CONFLICT    115    115       G -> V (in Ref. 4).
FT   CONFLICT    140    140       Y -> V (in Ref. 4).
FT   CONFLICT    277    277       Q -> E (in Ref. 4).
FT   CONFLICT    318    318       F -> L (in Ref. 4).
FT   STRAND       23     32
FT   STRAND       27     36
FT   STRAND       41     43
FT   STRAND       45     52
FT   STRAND       55     61
FT   STRAND       64     66
FT   HELIX        74     76
FT   HELIX        81    108
FT   STRAND      113    115
FT   STRAND      118    127
FT   STRAND      131    142
FT   STRAND      145    150
FT   STRAND      154    161
FT   HELIX       162    173
FT   HELIX       176    184
FT   HELIX       187    198
FT   HELIX       200    203
FT   STRAND      210    235
FT   STRAND      238    243
FT   STRAND      246    248
FT   STRAND      252    254
FT   STRAND      261    263
FT   STRAND      265    274
FT   HELIX       278    280
FT   STRAND      281    286
FT   STRAND      294    297
SQ   SEQUENCE   365 AA;  40922 MW;  B54A97B24B337C08 CRC64;
     MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV DLGTLRGYYN QSEAGSHTVQ
     RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL
     RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL
     TACKV
//
ID   1A02_PANTR              Reviewed;         362 AA.
AC   P16210;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   01-MAY-2007, entry version 51.
DE   CHLA class I histocompatibility antigen, A-5 alpha chain precursor.
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=90201944; PubMed=1690682;
RA   Lawlor D.A., Warren E., Ward F.E., Parham P.;
RT   "Comparison of class I MHC alleles in humans and apes.";
RL   Immunol. Rev. 113:147-185(1990).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; M30679; AAA87971.1; -; mRNA.
DR   PIR; I36962; I36962.
DR   HSSP; P30474; 1A9E.
DR   SMR; P16210; 25-300.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    362       CHLA class I histocompatibility antigen,
FT                                A-5 alpha chain.
FT                                /FTId=PRO_0000018911.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    362       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   362 AA;  40487 MW;  9B5A674445037056 CRC64;
     MQVTAPRTVL LLLSAALALT ETWAGSHSMK YFYTAVSRPG RGEPRFISVG YVDDTQFVWF
     DSDAASPREE PRAPWIEQEG PEYWDRETQI SKTNAQTYRE SLRNLRGYYN QSEAGSHIIQ
     RMYGCDMGPD GRLLRGYEQY AYDGKDYIAL NQDLSSWTAA DTAAQITQRK WEAARWAEQL
     RAYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
     SSQSTIPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL
     TA
//
ID   1A03_GORGO              Reviewed;         365 AA.
AC   P30377;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 48.
DE   Class I histocompatibility antigen, GOGO-A0401 alpha chain precursor.
OS   Gorilla gorilla gorilla (Lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92078860; PubMed=1744581; DOI=10.1084/jem.174.6.1491;
RA   Lawlor D.A., Warren E., Taylor P., Parham P.;
RT   "Gorilla class I major histocompatibility complex alleles: comparison
RT   to human and chimpanzee class I.";
RL   J. Exp. Med. 174:1491-1509(1991).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X60257; CAA42809.1; -; mRNA.
DR   PIR; JH0536; JH0536.
DR   HSSP; P10315; 1HSB.
DR   SMR; P30377; 25-299.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    365       Class I histocompatibility antigen, GOGO-
FT                                A0401 alpha chain.
FT                                /FTId=PRO_0000018899.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   365 AA;  40934 MW;  9207ABBDF9B406C9 CRC64;
     MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEE PEYWDGETRN MKARSQTDRV DLGTLRGYYN QSEDGSHTIQ
     RMYGCDVGSD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAAHEAEQL
     RAYLEGTCVE WLRRYLENGK ETLQLTDAPK THMTHHPVSD HEAILRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDVSL
     TACKV
//
ID   1A03_HUMAN              Reviewed;         365 AA.
AC   P04439; O19546; O19756; Q65A82; Q9GJE6; Q9GJE7; Q9GJE8; Q9MYG4;
AC   Q9TPR8;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2003, sequence version 2.
DT   01-MAY-2007, entry version 70.
DE   HLA class I histocompatibility antigen, A-3 alpha chain precursor (MHC
DE   class I antigen A*3).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0301).
RX   MEDLINE=84207948; PubMed=6609814;
RA   Strachan T., Sodoyer R., Damotte M., Jordan B.R.;
RT   "Complete nucleotide sequence of a functional class I HLA gene, HLA-
RT   A3: implications for the evolution of HLA genes.";
RL   EMBO J. 3:887-894(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0301).
RA   Ellexson M.E., Hildebrand W.H.;
RL   Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE A*0301).
RA   Shiina S., Tamiya G., Oka A., Inoko H.;
RT   "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0302).
RX   MEDLINE=85290871; PubMed=2993417;
RA   Cowan E.P., Jordan B.E., Coligan J.E.;
RT   "Molecular cloning and DNA sequence analysis of genes encoding
RT   cytotoxic T lymphocyte-defined HLA-A3 subtypes: the E1 subtype.";
RL   J. Immunol. 135:2835-2841(1985).
RN   [5]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*0302).
RA   Bettinotti M.P., Hadzikadic L., Adams S., Marincola F.M.;
RT   "Complete coding sequence of HLA-A*0302.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Mayor N.P.;
RT   "Full length sequence of an HLA-A*0301 intron 2 variant.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22935763; PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-341 (ALLELE A*0304).
RX   MEDLINE=99180630; PubMed=10079303; DOI=10.1007/s002510050506;
RA   Santos S., Balas A., Garcia-Sanchez F., Lillo R., Merino J.L.,
RA   Vicario J.L.;
RT   "Complete cDNA coding sequence of a new HLA-A3 subtype (A*0304) with a
RT   new HLA polymorphism at exon 3.";
RL   Immunogenetics 49:360-361(1999).
RN   [9]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*0305).
RA   Becher M.P., Wu J., Williams T.;
RT   "Novel human HLA-A alleles identified in potential bone marrow
RT   donors.";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE OF 26-298 (ALLELE A*0305).
RC   TISSUE=Blood;
RA   Poli F., Frison S., Crespiatico L., Longhi E.;
RT   "Identification of a HLA-A*03 new variant.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Dimer of alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-3 are known: A*0301 (A-
CC       3.1), A*0302, A*0304 and A*0305. The sequence shown is that of
CC       A*0301.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X00492; CAA25162.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; U32184; AAB63980.1; -; mRNA.
DR   EMBL; BA000025; BAB63400.1; -; Genomic_DNA.
DR   EMBL; AF217561; AAF28734.1; -; mRNA.
DR   EMBL; AF015930; AAB66582.1; -; mRNA.
DR   EMBL; AF190719; AAF03243.1; -; Genomic_DNA.
DR   EMBL; AF190718; AAF03243.1; JOINED; Genomic_DNA.
DR   EMBL; AJ401085; CAC06086.1; -; Genomic_DNA.
DR   EMBL; AJ401086; CAC06087.1; -; Genomic_DNA.
DR   EMBL; AJ401087; CAC06088.1; -; Genomic_DNA.
DR   EMBL; AJ748743; CAG38621.1; -; Genomic_DNA.
DR   EMBL; AL671277; CAI18372.1; -; Genomic_DNA.
DR   PIR; A02192; HLHUA3.
DR   UniGene; Hs.181244; -.
DR   HSSP; P10315; 1HSB.
DR   SMR; P04439; 25-299.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   KEGG; hsa:3105; -.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P04439; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
DR   GO; GO:0032393; F:MHC class I receptor activity; NAS:UniProtKB.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-3 alpha chain.
FT                                /FTId=PRO_0000018815.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT     176    176       E -> V (in allele A*0302).
FT                                /FTId=VAR_004351.
FT   VARIANT     180    180       L -> Q (in allele A*0302).
FT                                /FTId=VAR_004352.
FT   VARIANT     185    185       D -> E (in allele A*0305).
FT                                /FTId=VAR_016604.
FT   VARIANT     199    199       G -> R (in allele A*0304).
FT                                /FTId=VAR_016605.
FT   CONFLICT    319    319       G -> A (in Ref. 8).
SQ   SEQUENCE   365 AA;  40841 MW;  DEDFCEC4450E0580 CRC64;
     MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEAGSHTIQ
     IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHEAEQL
     RAYLDGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
     SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL
     TACKV
//
ID   1A03_PANTR              Reviewed;         365 AA.
AC   P13748; Q547D5;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 2.
DT   01-MAY-2007, entry version 54.
DE   CHLA class I histocompatibility antigen, A-108 alpha chain precursor
DE   (MHC class I antigen Patr-A*0301).
GN   Name=Patr-A;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=89030641; PubMed=2460344;
RA   Mayer W.E., Jonker M., Klein D., Ivanyi P., van Seventer G., Klein J.;
RT   "Nucleotide sequences of chimpanzee MHC class I alleles: evidence for
RT   trans-species mode of evolution.";
RL   EMBO J. 7:2765-2774(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=22016141; PubMed=12021342;
RX   DOI=10.1128/JVI.76.12.6093-6103.2002;
RA   Mizukoshi E., Nascimbeni M., Blaustein J.B., Mihalik K., Rice C.M.,
RA   Liang T.J., Feinstone S.M., Rehermann B.;
RT   "Molecular and immunological significance of chimpanzee major
RT   histocompatibility complex haplotypes for hepatitis C virus immune
RT   response and vaccination studies.";
RL   J. Virol. 76:6093-6103(2002).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X13113; CAA31505.1; ALT_INIT; mRNA.
DR   EMBL; AF500288; AAM49754.1; -; mRNA.
DR   PIR; S03535; S03535.
DR   HSSP; P10315; 1HSB.
DR   SMR; P13748; 25-299.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    365       CHLA class I histocompatibility antigen,
FT                                A-108 alpha chain.
FT                                /FTId=PRO_0000018912.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   365 AA;  40823 MW;  48CC757055221FC3 CRC64;
     MAVMPPRTLL LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDQETRN MKASAQTDRV DLGTLRGYYN QSEDGSHTIQ
     IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA AMAAQITKRK WEAAHAAEQL
     RAYLEGRCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAVITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL
     TACKV
//
ID   1A04_GORGO              Reviewed;         365 AA.
AC   P30378;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 49.
DE   Class I histocompatibility antigen, GOGO-A0501 alpha chain precursor.
OS   Gorilla gorilla gorilla (Lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92078860; PubMed=1744581; DOI=10.1084/jem.174.6.1491;
RA   Lawlor D.A., Warren E., Taylor P., Parham P.;
RT   "Gorilla class I major histocompatibility complex alleles: comparison
RT   to human and chimpanzee class I.";
RL   J. Exp. Med. 174:1491-1509(1991).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X60256; CAA42808.1; -; mRNA.
DR   PIR; JH0537; JH0537.
DR   HSSP; P10315; 1HSB.
DR   SMR; P30378; 25-302.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    365       Class I histocompatibility antigen, GOGO-
FT                                A0501 alpha chain.
FT                                /FTId=PRO_0000018900.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   365 AA;  40896 MW;  340DAD21F9B3B8AB CRC64;
     MAVVAPRTLL LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWMEQEE PEYWDRQTQI SKTNAQIELE SLRIALRYYN QSEDGSHTIQ
     RMYGCDVGSD GRFLRGYQQD AYDGKDYIAS NEDLRSWTAA DMAAEITKRK WEAAHFAEQL
     RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THTTHQAVSD HEATLKCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDVSL
     TACKV
//
ID   1A04_PANTR              Reviewed;         365 AA.
AC   P13749; Q7JJU4;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   01-MAY-2007, entry version 53.
DE   CHLA class I histocompatibility antigen, A-126 alpha chain precursor
DE   (MHC class I antigen Patr-A*0401).
GN   Name=Patr-A;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=89030641; PubMed=2460344;
RA   Mayer W.E., Jonker M., Klein D., Ivanyi P., van Seventer G., Klein J.;
RT   "Nucleotide sequences of chimpanzee MHC class I alleles: evidence for
RT   trans-species mode of evolution.";
RL   EMBO J. 7:2765-2774(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RX   MEDLINE=20322475; PubMed=10866106; DOI=10.1007/s002510050638;
RA   de Groot N.G., Otting N., Arguello R., Watkins D.I., Doxiadis G.G.,
RA   Madrigal J.A., Bontrop R.E.;
RT   "Major histocompatibility complex class I diversity in a West African
RT   chimpanzee population: implications for HIV research.";
RL   Immunogenetics 51:398-409(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22709134; PubMed=12799463; DOI=10.1073/pnas.1230533100;
RA   Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A.,
RA   Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y.,
RA   Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T.,
RA   Meyer A., Ikeo K., Gojobori T., Bahram S., Inoko H.;
RT   "Comparative sequencing of human and chimpanzee MHC class I regions
RT   unveils insertions/deletions as the major path to genomic
RT   divergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X13114; CAA31506.1; -; mRNA.
DR   EMBL; AF168401; AAF72782.1; -; mRNA.
DR   EMBL; BA000041; BAC78189.1; -; Genomic_DNA.
DR   PIR; S01171; S01171.
DR   HSSP; P10315; 1HSB.
DR   SMR; P13749; 25-299.
DR   KEGG; ptr:450151; -.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    365       CHLA class I histocompatibility antigen,
FT                                A-126 alpha chain.
FT                                /FTId=PRO_0000018913.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   365 AA;  40656 MW;  D3C9A810B22A768F CRC64;
     MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDEETRS VKASAQTDRV DLGTLRGYYN QSEDGSHTIQ
     LMFGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAAHAAEQL
     RAYLEGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD REATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL
     TACKV
//
ID   1A11_HUMAN              Reviewed;         365 AA.
AC   P13746; O19605; O19606; Q29747; Q29835; Q9BCN0; Q9MYI5; Q9TQE9;
AC   Q9TQP6; Q9TQP7;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   01-MAY-2007, entry version 71.
DE   HLA class I histocompatibility antigen, A-11 alpha chain precursor
DE   (MHC class I antigen A*11).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*1101 AND A*1102).
RX   MEDLINE=89030641; PubMed=2460344;
RA   Mayer W.E., Jonker M., Klein D., Ivanyi P., van Seventer G., Klein J.;
RT   "Nucleotide sequences of chimpanzee MHC class I alleles: evidence for
RT   trans-species mode of evolution.";
RL   EMBO J. 7:2765-2774(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*1101 AND A*1102).
RX   MEDLINE=94287401; PubMed=8016845;
RA   Lin L., Tokunaga K., Ishikawa Y., Bannai M., Kashiwase K., Kuwata S.,
RA   Akaza T., Tadokoro K., Shibata Y., Juji T.;
RT   "Sequence analysis of serological HLA-A11 split antigens, A11.1 and
RT   A11.2.";
RL   Tissue Antigens 43:78-82(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-365 (ALLELE A*1101).
RX   MEDLINE=87192928; PubMed=2437024; DOI=10.1007/BF00404694;
RA   Cowan E.P., Jelachich M.L., Biddison W.E., Coligan J.E.;
RT   "DNA sequence of HLA-A11: remarkable homology with HLA-A3 allows
RT   identification of residues involved in epitopes recognized by
RT   antibodies and T cells.";
RL   Immunogenetics 25:241-250(1987).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*1103).
RC   TISSUE=Blood;
RX   MEDLINE=20166353; PubMed=10703613;
RX   DOI=10.1034/j.1399-0039.2000.550113.x;
RA   Tijssen H.J., Sistermans E.A., van den Beucken M.J.G., Krausa P.,
RA   Joosten I.;
RT   "Complete sequence analysis of the A*1103 allele.";
RL   Tissue Antigens 55:68-70(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) (A*1103).
RC   TISSUE=Blood;
RX   MEDLINE=20340071; PubMed=10885562;
RX   DOI=10.1034/j.1399-0039.2000.550504.x;
RA   Tijssen H.J., Sistermans E.A., Joosten I.;
RT   "A unique second donor splice site in the intron 5 sequence of the
RT   HLA-A*11 alleles results in a class I transcript encoding a molecule
RT   with an elongated cytoplasmic domain.";
RL   Tissue Antigens 55:422-428(2000).
RN   [6]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*1104).
RA   Bettinotti M.P.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*1104).
RA   Chandanayingyong D., Sirikong M., Luangtrakool K., Srinak D.,
RA   Rungroung E., Bejchandra S.;
RT   "A11 alleles (A*11O4).";
RL   Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*1105).
RX   MEDLINE=99321035; PubMed=10395112;
RX   DOI=10.1034/j.1399-0039.1999.530612.x;
RA   Morrell G., Whalley J., Stewart A., Day S., Lewis L., Makar Y.,
RA   Ross J., Dunn P.P.;
RT   "Identification of an HLA-A11 serological variant and its
RT   characterization by sequencing based typing.";
RL   Tissue Antigens 53:591-594(1999).
RN   [9]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*1105).
RX   MEDLINE=20309230; PubMed=10852390;
RX   DOI=10.1034/j.1399-0039.2000.550412.x;
RA   Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R.,
RA   Ng J., Hartzman R.J., Hurley C.K.;
RT   "Seventeen more novel HLA-A locus alleles.";
RL   Tissue Antigens 55:369-373(2000).
RN   [10]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*1107).
RX   MEDLINE=21561663; PubMed=11703829;
RX   DOI=10.1034/j.1399-0039.2001.580309.x;
RA   Pyo C.W., Choi H.B., Han H., Hong Y.S., Kim T.G.;
RT   "Identification of HLA-A*11 variant (A*1107) in the Korean
RT   population.";
RL   Tissue Antigens 58:190-192(2001).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P13746-1; Sequence=Displayed;
CC       Name=2; Synonyms=Long;
CC         IsoId=P13746-2; Sequence=VSP_008099;
CC         Note=Only produced by allele A*1103;
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-11 are known: A*1101 (A-
CC       11E), A*1102 (A-11K), A*1103, A*1104, A*1105 and A*1107. The
CC       sequence shown is that of A*1101.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X13111; CAA31503.1; -; mRNA.
DR   EMBL; X13112; CAA31504.1; -; mRNA.
DR   EMBL; D16841; BAA04117.1; -; mRNA.
DR   EMBL; D16842; BAA04118.1; -; mRNA.
DR   EMBL; M16010; AAA65449.1; -; Genomic_DNA.
DR   EMBL; M16007; AAA65449.1; JOINED; Genomic_DNA.
DR   EMBL; M16008; AAA65449.1; JOINED; Genomic_DNA.
DR   EMBL; M16009; AAA65449.1; JOINED; Genomic_DNA.
DR   EMBL; Y17224; CAB38056.1; -; mRNA.
DR   EMBL; Y17224; CAB38057.1; -; mRNA.
DR   EMBL; X91399; CAA62745.1; -; mRNA.
DR   EMBL; U50574; AAB60406.1; -; mRNA.
DR   EMBL; AF030910; AAB87052.1; -; Genomic_DNA.
DR   EMBL; AF030909; AAB87052.1; JOINED; Genomic_DNA.
DR   EMBL; AF030908; AAB87051.1; -; Genomic_DNA.
DR   EMBL; AF030907; AAB87051.1; JOINED; Genomic_DNA.
DR   EMBL; AJ306733; CAC37336.1; -; Genomic_DNA.
DR   EMBL; AF147455; AAD33991.1; -; Genomic_DNA.
DR   EMBL; AF147454; AAD33991.1; JOINED; Genomic_DNA.
DR   EMBL; AF165065; AAF25781.1; -; mRNA.
DR   PIR; I83063; I83063.
DR   PIR; S03536; A47636.
DR   UniGene; Hs.181244; -.
DR   PDB; 1Q94; X-ray; A/D=25-299.
DR   PDB; 1QVO; X-ray; A/D=25-299.
DR   PDB; 1X7Q; X-ray; A=25-299.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P13746; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
DR   GO; GO:0032393; F:MHC class I receptor activity; NAS:UniProtKB.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   3D-structure; Alternative splicing; Glycoprotein;
KW   Host-virus interaction; Immune response; Membrane; MHC I;
KW   Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-11 alpha chain.
FT                                /FTId=PRO_0000018816.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VAR_SEQ     337    337       S -> SGGEGVK (in isoform 2).
FT                                /FTId=VSP_008099.
FT   VARIANT      43     43       E -> K (in allele A*1102).
FT                                /FTId=VAR_004353.
FT   VARIANT     133    133       F -> L (in allele A*1107).
FT                                /FTId=VAR_016731.
FT   VARIANT     168    168       K -> E (in allele A*1105).
FT                                /FTId=VAR_016732.
FT   VARIANT     175    175       H -> R (in allele A*1103).
FT                                /FTId=VAR_016733.
FT   VARIANT     176    176       A -> E (in allele A*1103).
FT                                /FTId=VAR_016734.
FT   VARIANT     187    187       R -> T (in allele A*1104).
FT                                /FTId=VAR_016735.
FT   VARIANT     345    345       T -> S (in allele A*1105).
FT                                /FTId=VAR_016736.
FT   STRAND       27     36
FT   STRAND       41     43
FT   STRAND       45     52
FT   STRAND       55     61
FT   STRAND       64     66
FT   HELIX        74     76
FT   HELIX        81    108
FT   STRAND      113    115
FT   STRAND      118    127
FT   STRAND      133    142
FT   STRAND      145    150
FT   STRAND      157    159
FT   HELIX       162    173
FT   HELIX       176    185
FT   HELIX       187    198
FT   HELIX       200    203
FT   STRAND      210    217
FT   STRAND      219    235
FT   STRAND      238    243
FT   STRAND      252    254
FT   STRAND      261    263
FT   STRAND      265    274
FT   HELIX       278    280
FT   STRAND      281    286
FT   STRAND      294    297
SQ   SEQUENCE   365 AA;  40937 MW;  FE449CE2D4BF6CC5 CRC64;
     MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEDGSHTIQ
     IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHAAEQQ
     RAYLEGRCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
     SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL
     TACKV
//
ID   1A23_HUMAN              Reviewed;         365 AA.
AC   P30447; Q9TQF1; Q9TQF8; Q9TQG5; Q9TQM6;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 59.
DE   HLA class I histocompatibility antigen, A-23 alpha chain precursor
DE   (MHC class I antigen A*23) (A-9).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*2301).
RX   MEDLINE=92104637; PubMed=1729171; DOI=10.1007/BF00216625;
RA   Little A.-M., Madrigal J.A., Parham P.;
RT   "Molecular definition of an elusive third HLA-A9 molecule: HLA-A9.3.";
RL   Immunogenetics 35:41-45(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*2302 AND A*2303).
RX   MEDLINE=20309230; PubMed=10852390;
RX   DOI=10.1034/j.1399-0039.2000.550412.x;
RA   Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R.,
RA   Ng J., Hartzman R.J., Hurley C.K.;
RT   "Seventeen more novel HLA-A locus alleles.";
RL   Tissue Antigens 55:369-373(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*2304 AND A*2305).
RX   MEDLINE=21068830; PubMed=11169246;
RX   DOI=10.1034/j.1399-0039.2000.560610.x;
RA   Steiner N.K., Edson S.M., Mitton W., Ng J., Hartzman R.J.,
RA   Hurley C.K.;
RT   "Seven novel HLA-A alleles carry previously observed polymorphisms.";
RL   Tissue Antigens 56:551-552(2000).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-23 are known: A*2301,
CC       A*2302, A*2303, A*2304 and A*2305. The sequence shown is that of
CC       A*2301.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; M64742; AAA03662.1; -; Unassigned_RNA.
DR   EMBL; AF137080; AAD33736.1; -; Genomic_DNA.
DR   EMBL; AF137079; AAD33736.1; JOINED; Genomic_DNA.
DR   EMBL; AF102572; AAD28171.1; -; Genomic_DNA.
DR   EMBL; AF102571; AAD28171.1; JOINED; Genomic_DNA.
DR   EMBL; AF135549; AAD22272.1; -; Genomic_DNA.
DR   EMBL; AF135548; AAD22272.1; JOINED; Genomic_DNA.
DR   EMBL; AF140860; AAD31878.1; -; Genomic_DNA.
DR   EMBL; AF140859; AAD31878.1; JOINED; Genomic_DNA.
DR   HSSP; Q29961; 1HSA.
DR   SMR; P30447; 25-302.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P30447; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-23 alpha chain.
FT                                /FTId=PRO_0000018817.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT      31     31       Y -> C (in allele A*2305).
FT                                /FTId=VAR_016606.
FT   VARIANT     151    151       K -> N (in allele A*2303).
FT                                /FTId=VAR_016607.
FT   VARIANT     180    180       L -> W (in allele A*2302).
FT                                /FTId=VAR_016608.
FT   VARIANT     190    191       DG -> EW (in allele A*2304).
FT                                /FTId=VAR_016609.
SQ   SEQUENCE   365 AA;  40733 MW;  C372DE503BF393D0 CRC64;
     MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDEETGK VKAHSQTDRE NLRIALRYYN QSEAGSHTLQ
     MMFGCDVGSD GRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQITQRK WEAARVAEQL
     RAYLEGTCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTVHIVG IIAGLVLLGA VITGAVVAAV MWRRNSSDRK GGSYSQAASS DSAQGSDVSL
     TACKV
//
ID   1A24_HUMAN              Reviewed;         365 AA.
AC   P05534; P30448; P30449; Q29908; Q29909; Q29910; Q95355;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2003, sequence version 2.
DT   01-MAY-2007, entry version 81.
DE   HLA class I histocompatibility antigen, A-24 alpha chain precursor
DE   (MHC class I antigen A*24) (Aw-24) (A-9).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*2401).
RX   MEDLINE=85206128; PubMed=2987115;
RA   N'Guyen C., Sodoyer R., Trucy J., Strachan T., Jordan B.R.;
RT   "The HLA-AW24 gene: sequence, surroundings and comparison with the
RT   HLA-A2 and HLA-A3 genes.";
RL   Immunogenetics 21:479-489(1985).
RN   [2]
RP   SEQUENCE REVISION.
RA   Jordan B.R.;
RL   Submitted (JUL-1988) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELES A*2402 AND A*2403).
RX   MEDLINE=92104637; PubMed=1729171; DOI=10.1007/BF00216625;
RA   Little A.-M., Madrigal J.A., Parham P.;
RT   "Molecular definition of an elusive third HLA-A9 molecule: HLA-A9.3.";
RL   Immunogenetics 35:41-45(1992).
RN   [4]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*2402).
RX   MEDLINE=92269955; PubMed=1317015; DOI=10.1038/357326a0;
RA   Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J.,
RA   Williams R.C., Luz R., Petzl-Erler M.L., Parham P.;
RT   "Unusual HLA-B alleles in two tribes of Brazilian Indians.";
RL   Nature 357:326-329(1992).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*2402).
RX   MEDLINE=98007772; PubMed=9349616;
RA   Laforet M., Froelich N., Parissiadis A., Bausinger H., Pfeiffer B.,
RA   Tongio M.M.;
RT   "An intronic mutation responsible for a low level of expression of an
RT   HLA-A*24 allele.";
RL   Tissue Antigens 50:340-346(1997).
RN   [6]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*2408).
RC   TISSUE=Blood;
RA   Kashiwase K., Tokunaga K., Ishikawa Y., Qiu L., Furuya M.,
RA   Sawanaka K., Akaza T., Tadokoro K., Juji T.;
RT   "Sequence analysis of a serological subtype, HLA-A9HH, observed in
RT   Japanese and the confirmatory sequence of A*2408.";
RL   MHC 3:9-14(1996).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*2410).
RC   TISSUE=Blood;
RX   MEDLINE=97161044; PubMed=9008316;
RA   Gao X., Matheson B.;
RT   "A novel HLA-A*24 (A*2410) identified in a Javanese population.";
RL   Tissue Antigens 48:711-713(1996).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES A*2406; A*2413
RP   AND A*2414).
RC   TISSUE=Blood;
RX   MEDLINE=97417771; PubMed=9271829;
RA   Gao X., Lester S., Matheson B., Boettcher B., McCluskey J.;
RT   "Three newly identified A*24 alleles: A*2406, A*2413 and A*2414.";
RL   Tissue Antigens 50:192-196(1997).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-24 are known: A*2401,
CC       A*2402, A*2403, A*2406, A*2408 (A9HH), A*2410 (A*24JV), A*2413
CC       (A*24YM) and A*2414 (A*24SA). Allele A*2402 is represented in all
CC       major racial groups. Allele A*2406 and allele A*2413 are found in
CC       the Australian Aborigenal population. Allele A*2414 is found in
CC       individuals of South American descent. The sequence shown is that
CC       of A*2402.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; M15497; AAA59611.1; -; Genomic_DNA.
DR   EMBL; M64740; AAA59600.1; -; mRNA.
DR   EMBL; M64741; AAA59601.1; -; Genomic_DNA.
DR   EMBL; Z72422; CAA96532.1; -; Genomic_DNA.
DR   EMBL; D83516; BAA11936.1; -; mRNA.
DR   EMBL; U37111; AAA83264.1; -; Genomic_DNA.
DR   EMBL; U37110; AAA83264.1; JOINED; Genomic_DNA.
DR   EMBL; U37113; AAA83265.1; -; Genomic_DNA.
DR   EMBL; U37112; AAA83265.1; JOINED; Genomic_DNA.
DR   EMBL; U37115; AAB40048.1; -; Genomic_DNA.
DR   EMBL; U37114; AAB40048.1; JOINED; Genomic_DNA.
DR   EMBL; U19733; AAB60651.1; -; Genomic_DNA.
DR   EMBL; U18987; AAB60651.1; JOINED; Genomic_DNA.
DR   PIR; I54416; I54416.
DR   UniGene; Hs.181244; -.
DR   PDB; 2BCK; X-ray; A/D=25-302.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P05534; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   3D-structure; Glycoprotein; Host-virus interaction; Immune response;
KW   Membrane; MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-24 alpha chain.
FT                                /FTId=PRO_0000018818.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT       5      5       A -> G (in allele A*2401).
FT                                /FTId=VAR_004354.
FT   VARIANT      27     27       H -> Q (in allele A*2408).
FT                                /FTId=VAR_004355.
FT   VARIANT      86     86       E -> G (in allele A*2408).
FT                                /FTId=VAR_004356.
FT   VARIANT      89     89       G -> R (in allele A*2408).
FT                                /FTId=VAR_004357.
FT   VARIANT     119    119       L -> V (in allele A*2414).
FT                                /FTId=VAR_015765.
FT   VARIANT     121    121       M -> R (in allele A*2414).
FT                                /FTId=VAR_015766.
FT   VARIANT     123    123       F -> Y (in allele A*2414).
FT                                /FTId=VAR_015767.
FT   VARIANT     131    131       G -> W (in allele A*2414).
FT                                /FTId=VAR_015768.
FT   VARIANT     180    180       Q -> L (in allele A*2413).
FT                                /FTId=VAR_015769.
FT   VARIANT     180    180       Q -> W (in allele A*2406; requires 2
FT                                nucleotide substitutions).
FT                                /FTId=VAR_004358.
FT   VARIANT     187    187       T -> R (in allele A*2410).
FT                                /FTId=VAR_015770.
FT   VARIANT     190    191       DG -> EW (in allele A*2403 and allele
FT                                A*2410).
FT                                /FTId=VAR_004359.
FT   VARIANT     206    206       T -> A (in allele A*2401).
FT                                /FTId=VAR_004360.
FT   STRAND       27     36
FT   STRAND       41     43
FT   STRAND       45     52
FT   STRAND       55     61
FT   STRAND       64     66
FT   HELIX        74     76
FT   HELIX        81    108
FT   STRAND      118    127
FT   STRAND      133    142
FT   STRAND      145    150
FT   STRAND      157    159
FT   HELIX       162    173
FT   HELIX       176    185
FT   HELIX       187    197
FT   HELIX       200    203
FT   STRAND      212    217
FT   STRAND      219    235
FT   STRAND      238    243
FT   HELIX       249    251
FT   STRAND      252    254
FT   STRAND      261    263
FT   STRAND      265    274
FT   HELIX       278    280
FT   STRAND      281    286
FT   STRAND      290    292
FT   STRAND      294    296
FT   STRAND      298    302
SQ   SEQUENCE   365 AA;  40689 MW;  D33684D126F98EC3 CRC64;
     MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDEETGK VKAHSQTDRE NLRIALRYYN QSEAGSHTLQ
     MMFGCDVGSD GRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQITKRK WEAAHVAEQQ
     RAYLEGTCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTVPIVG IIAGLVLLGA VITGAVVAAV MWRRNSSDRK GGSYSQAASS DSAQGSDVSL
     TACKV
//
ID   1A25_HUMAN              Reviewed;         365 AA.
AC   P18462; Q95362; Q9TQE8; Q9TQG0; Q9UQU3;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   01-MAY-2007, entry version 70.
DE   HLA class I histocompatibility antigen, A-25 alpha chain precursor
DE   (MHC class I antigen A*25) (A-10).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*2501).
RX   MEDLINE=90207291; PubMed=2320591;
RA   Ennis P.D., Zemmour J., Salter R.D., Parham P.;
RT   "Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction:
RT   frequency and nature of errors produced in amplification.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE A*2501).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*2502).
RC   TISSUE=Hematopoietic;
RX   MEDLINE=97045042; PubMed=8881046; DOI=10.1007/s002510050175;
RA   Krausa P., Young D.M., Gotch F.;
RT   "Identification of a new HLA-A allele (A*2502) by PCR-SSP.";
RL   Immunogenetics 45:84-85(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*2502).
RA   Guttridge M.G.;
RT   "Sequence confirmation of HLA-A*2502.";
RL   Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*2503).
RX   MEDLINE=20309230; PubMed=10852390;
RX   DOI=10.1034/j.1399-0039.2000.550412.x;
RA   Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R.,
RA   Ng J., Hartzman R.J., Hurley C.K.;
RT   "Seventeen more novel HLA-A locus alleles.";
RL   Tissue Antigens 55:369-373(2000).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-25 are known: A*2501
CC       A*2502 and A*2503. The sequence shown is that of A*2501.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; M32321; AAA36234.1; -; mRNA.
DR   EMBL; BC008611; AAH08611.1; -; mRNA.
DR   EMBL; X97802; CAA66389.1; -; mRNA.
DR   EMBL; AJ238524; CAB41888.1; -; Genomic_DNA.
DR   EMBL; AF137076; AAD33737.1; -; Genomic_DNA.
DR   EMBL; AF137075; AAD33737.1; JOINED; Genomic_DNA.
DR   EMBL; AF148898; AAD34010.1; -; Genomic_DNA.
DR   EMBL; AF148897; AAD34010.1; JOINED; Genomic_DNA.
DR   UniGene; Hs.181244; -.
DR   HSSP; P10315; 1HSB.
DR   SMR; P18462; 25-299.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P18462; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-25 alpha chain.
FT                                /FTId=PRO_0000018819.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT      33     33       Y -> F (in allele A*2503).
FT                                /FTId=VAR_016737.
FT   VARIANT      94     94       H -> Q (in allele A*2502).
FT                                /FTId=VAR_004361.
SQ   SEQUENCE   365 AA;  41218 MW;  00F71BD2F97C3620 CRC64;
     MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRE SLRIALRYYN QSEDGSHTIQ
     RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW
     RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDMSL
     TACKV
//
ID   1A26_HUMAN              Reviewed;         365 AA.
AC   P30450; O02963; O78073; P79563; Q30208; Q31623; Q95377; Q9BD15;
AC   Q9BD19; Q9MW42; Q9TQK5;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   01-MAY-2007, entry version 67.
DE   HLA class I histocompatibility antigen, A-26 alpha chain precursor
DE   (MHC class I antigen A*26).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ALLELES A*2601 AND A*2602).
RX   MEDLINE=93235211; PubMed=8475492;
RA   Madrigal J.A., Hildebrand W.H., Belich M.P., Benjamin R.J.,
RA   Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L.,
RA   du Toit E.D., Parham P.;
RT   "Structural diversity in the HLA-A10 family of alleles: correlations
RT   with serology.";
RL   Tissue Antigens 41:72-80(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*2601).
RX   MEDLINE=90256559; PubMed=1692821; DOI=10.1016/0198-8859(90)90047-S;
RA   Zinzsner H., Masset M., Bourge J.-F., Colombani J., Cohen D.,
RA   Degos L., Paul P.;
RT   "Nucleotide sequence of the HLA-A26 class I gene: identification of
RT   specific residues and molecular mapping of public HLA class I
RT   epitopes.";
RL   Hum. Immunol. 27:155-166(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*2601; A*2602; A*2603 AND
RP   A*2604).
RC   TISSUE=Blood;
RX   MEDLINE=94299439; PubMed=8026990; DOI=10.1016/0198-8859(94)90263-1;
RA   Ishikawa Y., Tokunaga K., Lin L., Imanishi T., Saitou S.,
RA   Kashiwase K., Akaza T., Tadokoro K., Juji T.;
RT   "Sequences of four splits of HLA-A10 group. Implications for serologic
RT   cross-reactivities and their evolution.";
RL   Hum. Immunol. 39:220-224(1994).
RN   [4]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*2601).
RC   TISSUE=Lymphocyte;
RA   Miyashita H., Fujiyoshi T., Yashiki S., Kuwayama M., Fujiyama C.,
RA   Sonoda S.;
RL   Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*2603).
RC   TISSUE=Lymphocyte;
RX   MEDLINE=96435465; PubMed=8838351;
RA   Miyashita H., Fujiyoshi T., Yashiki S., Kuwayama M., Fujiyama C.,
RA   Sonoda S.;
RT   "Cloning of HLA-A26 cDNA from Japanese donors possessing 'ATL-
RT   associated HLA haplotypes'.";
RL   Tissue Antigens 46:398-400(1995).
RN   [6]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*2605).
RC   TISSUE=Blood;
RA   Maruya E., Ishikawa Y., Lin L., Tokunaga K., Kimura A., Saitou S.,
RA   Nita H., Juji T., Saji H.;
RT   "A novel A26 sequence found in Japanese, and identification of four
RT   major HLA-A26 subtypes.";
RL   Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*2607).
RX   MEDLINE=96387673; PubMed=8795143;
RA   Arnett K.L., Moses J.H., Williams F., Marsh S.G.E., Bodmer J.G.,
RA   Parham P., Middleton D.;
RT   "HLA-A *2607: sequence of a novel A*26 subtype predicted by DNA typing
RT   which shares the MA2.1 epitope with A*02, B*57 and B*58.";
RL   Tissue Antigens 47:422-425(1996).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*2608).
RX   MEDLINE=97051455; PubMed=8896181;
RA   Szmania S., Baxter-Lowe L.A.;
RT   "Nucleotide sequence for HLA-A*2608 which encodes glutamine at codon
RT   156.";
RL   Tissue Antigens 48:210-212(1996).
RN   [9]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*2608).
RA   Ellexson M.E., Hildebrand W.H.;
RL   Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*2612).
RX   MEDLINE=20548605; PubMed=11098929;
RX   DOI=10.1034/j.1399-0039.2000.560401.x;
RA   Ellis J.M., Mack S.J., Leke R.F.G., Quakyi I., Johnson A.H.,
RA   Hurley C.K.;
RT   "Diversity is demonstrated in class I HLA-A and HLA-B alleles in
RT   Cameroon, Africa: description of HLA-A*03012, *2612, *3006 and HLA-
RT   B*1403, *4016, *4703.";
RL   Tissue Antigens 56:291-302(2000).
RN   [11]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*2612).
RX   MEDLINE=21160440; PubMed=11260503;
RX   DOI=10.1034/j.1399-0039.2001.057002095.x;
RA   Hickman H.D., Cavett J.W., Ellexson-Turner M.E., Sparkman J.N.,
RA   Bennett T.T., Turner S., Sidebottom D.A., Trachtenberg E.A.,
RA   Confer D.L., Hildebrand W.H.;
RT   "Non-conservative substitutions distinguish previously uncharacterized
RT   HLA-A molecules.";
RL   Tissue Antigens 57:95-102(2001).
RN   [12]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*2615).
RA   Voorter C.E., Gervais T., van den Berg-Loonene E.M.;
RT   "New HLA-A alleles detected by sequence-based typing.";
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN   [13]
RP   NUCLEOTIDE SEQUENCE OF 26-298 (ALLELE A*2607).
RA   Moine A.;
RT   "A new variant form of a HLA A*2607 allele.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [14]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 27-365 (ALLELE A*2601).
RX   MEDLINE=89122144; PubMed=2914713;
RA   Cianetti L., Testa U., Scotto L., la Valle R., Simeone A., Boccoli G.,
RA   Giannella G., Peschle C., Boncinelli E.;
RT   "Three new class I HLA alleles: structure of mRNAs and alternative
RT   mechanisms of processing.";
RL   Immunogenetics 29:80-91(1989).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- INTERACTION:
CC       P16188:HLA-A; NbExp=1; IntAct=EBI-1042870, EBI-1044129;
CC       Q53QP2:UGCGL1; NbExp=1; IntAct=EBI-1042870, EBI-1056389;
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-26 are known: A*2601,
CC       A*2602, A*2603, A*2604 (A-10SA), A*2605, A*2607, A*2608, A*2612
CC       and A*2615. The sequence shown is that of A*2601.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; U03697; AAA03720.1; -; mRNA.
DR   EMBL; M98453; AAA35991.1; -; mRNA.
DR   EMBL; D14350; BAA03279.1; -; mRNA.
DR   EMBL; D14351; BAA03280.1; -; mRNA.
DR   EMBL; D14354; BAA03282.1; -; mRNA.
DR   EMBL; D16843; BAA04119.1; -; mRNA.
DR   EMBL; D32130; BAA06856.1; -; mRNA.
DR   EMBL; D32131; BAA06857.1; -; mRNA.
DR   EMBL; D32129; BAA06855.1; -; mRNA.
DR   EMBL; D50068; BAA08783.1; -; mRNA.
DR   EMBL; L48341; AAF25960.1; -; Genomic_DNA.
DR   EMBL; U52429; AAB08574.1; -; mRNA.
DR   EMBL; U45480; AAB38491.1; -; mRNA.
DR   EMBL; AF065487; AAC17438.1; -; Genomic_DNA.
DR   EMBL; AF065486; AAC17438.1; JOINED; Genomic_DNA.
DR   EMBL; AF042187; AAD02210.1; -; Genomic_DNA.
DR   EMBL; AF042186; AAD02210.1; JOINED; Genomic_DNA.
DR   EMBL; AJ291695; CAC27239.1; -; Genomic_DNA.
DR   EMBL; AJ291696; CAC27239.1; JOINED; Genomic_DNA.
DR   EMBL; AJ290394; CAC27416.2; -; mRNA.
DR   EMBL; M24095; AAA59655.1; -; mRNA.
DR   PIR; I38436; I38436.
DR   UniGene; Hs.181244; -.
DR   HSSP; P10315; 1HSB.
DR   SMR; P30450; 25-299.
DR   IntAct; P30450; -.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P30450; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-26 alpha chain.
FT                                /FTId=PRO_0000018820.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT      60     60       F -> L (in allele A*2615).
FT                                /FTId=VAR_016341.
FT   VARIANT      86     87       RN -> GE (in allele A*2607).
FT                                /FTId=VAR_016342.
FT   VARIANT      90     90       N -> K (in allele A*2607).
FT                                /FTId=VAR_016343.
FT   VARIANT      98    101       DRAN -> HRVD (in allele A*2603).
FT                                /FTId=VAR_004362.
FT   VARIANT     100    100       A -> E (in allele A*2605).
FT                                /FTId=VAR_016344.
FT   VARIANT     140    140       D -> N (in allele A*2602).
FT                                /FTId=VAR_004364.
FT   VARIANT     176    176       E -> V (in allele A*2612).
FT                                /FTId=VAR_016345.
FT   VARIANT     180    180       W -> Q (in allele A*2608; requires 2
FT                                nucleotide substitutions).
FT                                /FTId=VAR_016346.
FT   VARIANT     187    187       R -> L (in allele A*2604).
FT                                /FTId=VAR_004363.
FT   VARIANT     306    306       I -> V (in dbSNP:rs1136949).
FT                                /FTId=VAR_014603.
FT   CONFLICT    153    153       D -> H (in Ref. 14).
FT   CONFLICT    160    160       A -> G (in Ref. 14).
SQ   SEQUENCE   365 AA;  41062 MW;  44B54DD363B46EDA CRC64;
     MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ
     RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW
     RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDMSL
     TACKV
//
ID   1A29_HUMAN              Reviewed;         365 AA.
AC   P30512; O02955; O19687; O98011; P30451; P79562;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   01-MAY-2007, entry version 67.
DE   HLA class I histocompatibility antigen, A-29 alpha chain precursor
DE   (MHC class I antigen A*29) (Aw-19).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*2901).
RX   MEDLINE=89065816; PubMed=2461903;
RA   Trapani J.A., Mizuno S., Kang S.H., Yang S.Y., Dupont B.;
RT   "Molecular mapping of a new public HLA class I epitope shared by all
RT   HLA-B and HLA-C antigens and defined by a monoclonal antibody.";
RL   Immunogenetics 29:25-32(1989).
RN   [2]
RP   SEQUENCE REVISION TO 345.
RA   Yang S.Y.;
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*2901).
RA   Szmania S., Baxter-Lowe L.A.;
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*2902).
RX   MEDLINE=92145462; PubMed=1782566;
RA   Tabary T., Prochnicka-Chalufour A., Cornillet P., Lehoang P.,
RA   Betuel H., Cohen H.M.;
RT   "HLA-A29 sub-types and 'Birdshot' choroido-retinopathy susceptibility:
RT   a possible 'resistance motif' in the HLA-A29.1 molecule.";
RL   C. R. Acad. Sci. III, Sci. Vie 313:599-605(1991).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELE A*2903).
RX   MEDLINE=98119601; PubMed=9459513;
RA   Prokupek B., Dunn P., Ross J., Jordan F., Holman R., Madrigal J.A.,
RA   Little A.-M.;
RT   "HLA-A*2903 expresses an epitope shared with HLA-A*8001.";
RL   Tissue Antigens 51:115-118(1998).
RN   [6]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*2904).
RX   MEDLINE=21160440; PubMed=11260503;
RX   DOI=10.1034/j.1399-0039.2001.057002095.x;
RA   Hickman H.D., Cavett J.W., Ellexson-Turner M.E., Sparkman J.N.,
RA   Bennett T.T., Turner S., Sidebottom D.A., Trachtenberg E.A.,
RA   Confer D.L., Hildebrand W.H.;
RT   "Non-conservative substitutions distinguish previously uncharacterized
RT   HLA-A molecules.";
RL   Tissue Antigens 57:95-102(2001).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-29 are known: A*2901
CC       (A29.1), A*2902 (A29.2), A*2903 and A*2904. The sequence shown is
CC       that of A*2901.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; M23739; AAB47873.1; -; mRNA.
DR   EMBL; U83415; AAB53373.1; -; mRNA.
DR   EMBL; X60108; CAA42702.1; -; mRNA.
DR   EMBL; AJ000661; CAA04209.1; -; mRNA.
DR   EMBL; Y09218; CAA70419.1; -; Genomic_DNA.
DR   EMBL; AF042189; AAD02224.1; -; Genomic_DNA.
DR   EMBL; AF042188; AAD02224.1; JOINED; Genomic_DNA.
DR   UniGene; Hs.181244; -.
DR   HSSP; P10315; 1HSB.
DR   SMR; P30512; 25-299.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P30512; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-29 alpha chain.
FT                                /FTId=PRO_0000018821.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT      90     90       N -> H (in allele A*2904).
FT                                /FTId=VAR_016347.
FT   VARIANT     126    126       H -> D (in allele A*2902, allele A*2903
FT                                and allele A*2904).
FT                                /FTId=VAR_004365.
FT   VARIANT     190    191       EW -> DG (in allele A*2903).
FT                                /FTId=VAR_010372.
SQ   SEQUENCE   365 AA;  40863 MW;  56E4B9039B3C783C CRC64;
     MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAQSQTDRA NLGTLRGYYN QSEAGSHTIQ
     MMYGCHVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL
     RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL
     TACKV
//
ID   1A30_HUMAN              Reviewed;         365 AA.
AC   P16188; O19598; O62921; P30452; Q9UIP7;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   01-MAY-2007, entry version 68.
DE   HLA class I histocompatibility antigen, A-30 alpha chain precursor
DE   (MHC class I antigen A*30).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*3001).
RX   MEDLINE=90038496; PubMed=2478623;
RA   Kato K., Trapani J.A., Allopenna J., Dupont B., Yang S.Y.;
RT   "Molecular analysis of the serologically defined HLA-Aw19 antigens. A
RT   genetically distinct family of HLA-A antigens comprising A29, A31,
RT   A32, and Aw33, but probably not A30.";
RL   J. Immunol. 143:3371-3378(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*3001).
RX   MEDLINE=95176329; PubMed=7871528;
RA   Olerup O., Daniels T.J., Baxter-Lowe L.;
RT   "Correct sequence of the A*3001 allele obtained by PCR-SSP typing and
RT   automated nucleotide sequencing.";
RL   Tissue Antigens 44:265-267(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*3002).
RX   MEDLINE=93056508; PubMed=1431115;
RA   Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J.,
RA   Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L.,
RA   Martell R.W., du Toit E.D., Parham P.;
RT   "Distinctive HLA-A,B antigens of black populations formed by
RT   interallelic conversion.";
RL   J. Immunol. 149:3411-3415(1992).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-279 (ALLELE A*3003).
RX   MEDLINE=93209813; PubMed=8458735; DOI=10.1016/0198-8859(93)90004-K;
RA   Choo S.Y., Starling G.C., Anasetti C., Hansen J.A.;
RT   "Selection of an unrelated donor for marrow transplantation
RT   facilitated by the molecular characterization of a novel HLA-A
RT   allele.";
RL   Hum. Immunol. 36:20-26(1993).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*3004).
RX   MEDLINE=96058597; PubMed=8522453; DOI=10.1016/0198-8859(95)00046-7;
RA   Krausa P., Carcassi C., Orru S., Bodmer J.G., Browning M.J., Contu L.;
RT   "Defining the allelic variants of HLA-A30 in the Sardinian population
RT   using amplification refractory mutation system -- polymerase chain
RT   reaction.";
RL   Hum. Immunol. 44:35-42(1995).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 26-206 (ALLELE A*3004).
RX   MEDLINE=96435464; PubMed=8838350;
RA   Lienert K., Russ G., Bennett G., Gao X., McCluskey J.;
RT   "HLA-A*3004: a new A30 allele identified in an Australian Caucasoid
RT   population.";
RL   Tissue Antigens 46:394-397(1995).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-205 (ALLELE A*3004).
RX   MEDLINE=96124443; PubMed=8560452;
RA   Blasczyk R., Wehling J., Paessler M., Hahn U., Huhn D., Salama A.;
RT   "A novel HLA-A30 allele (A*3004) identified by single-strand
RT   conformation polymorphism analysis and confirmed by solid-phase
RT   sequencing.";
RL   Tissue Antigens 46:322-326(1995).
RN   [8]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*3006).
RX   MEDLINE=20548605; PubMed=11098929;
RX   DOI=10.1034/j.1399-0039.2000.560401.x;
RA   Ellis J.M., Mack S.J., Leke R.F.G., Quakyi I., Johnson A.H.,
RA   Hurley C.K.;
RT   "Diversity is demonstrated in class I HLA-A and HLA-B alleles in
RT   Cameroon, Africa: description of HLA-A*03012, *2612, *3006 and HLA-
RT   B*1403, *4016, *4703.";
RL   Tissue Antigens 56:291-302(2000).
RN   [9]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*3007).
RX   MEDLINE=20309230; PubMed=10852390;
RX   DOI=10.1034/j.1399-0039.2000.550412.x;
RA   Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R.,
RA   Ng J., Hartzman R.J., Hurley C.K.;
RT   "Seventeen more novel HLA-A locus alleles.";
RL   Tissue Antigens 55:369-373(2000).
RN   [10]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*3008).
RX   MEDLINE=21108617; PubMed=11169261;
RX   DOI=10.1034/j.1399-0039.2001.057001070.x;
RA   Cox S.T., Mcwhinnie A.J., Koester R.P., Heine U., Holman R.,
RA   Madrigal A.J., Little A.-M.;
RT   "Further diversity at HLA-A and -B loci identified in Afro-Caribbean
RT   potential bone marrow donors.";
RL   Tissue Antigens 57:70-72(2001).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- INTERACTION:
CC       P30450:HLA-A; NbExp=1; IntAct=EBI-1044129, EBI-1042870;
CC       P30457:HLA-A; NbExp=1; IntAct=EBI-1044129, EBI-1049899;
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-30 are known: A*3001
CC       (A30.3), A*3002, A*3003, A*3004 (A30W7), A*3006, A*3007 and
CC       A*3008. The sequence shown is that of A*3001.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; M30576; AAA59612.1; -; Genomic_DNA.
DR   EMBL; U07234; AAA70162.1; -; mRNA.
DR   EMBL; X61702; CAA43871.1; -; mRNA.
DR   EMBL; M93657; AAA58650.1; -; Genomic_DNA.
DR   EMBL; Z34921; CAA84401.1; -; Genomic_DNA.
DR   EMBL; U19734; AAB53658.1; -; Genomic_DNA.
DR   EMBL; U18988; AAB53658.1; JOINED; Genomic_DNA.
DR   EMBL; U24261; AAB50434.1; -; mRNA.
DR   EMBL; X83770; CAA58723.1; -; Genomic_DNA.
DR   EMBL; X83771; CAA58724.1; -; Genomic_DNA.
DR   EMBL; AF028714; AAC14191.1; -; Genomic_DNA.
DR   EMBL; AF028713; AAC14191.1; JOINED; Genomic_DNA.
DR   EMBL; AF065643; AAC18600.1; -; Genomic_DNA.
DR   EMBL; AF065642; AAC18600.1; JOINED; Genomic_DNA.
DR   EMBL; AJ249308; CAB57306.1; -; Genomic_DNA.
DR   EMBL; AJ249309; CAB57306.1; JOINED; Genomic_DNA.
DR   EMBL; AJ249310; CAB57306.1; JOINED; Genomic_DNA.
DR   EMBL; AJ249311; CAB57306.1; JOINED; Genomic_DNA.
DR   EMBL; AJ249312; CAB57306.1; JOINED; Genomic_DNA.
DR   EMBL; AJ249313; CAB57306.1; JOINED; Genomic_DNA.
DR   EMBL; AJ249314; CAB57306.1; JOINED; Genomic_DNA.
DR   EMBL; AJ249315; CAB57306.1; JOINED; Genomic_DNA.
DR   PIR; I38519; I38519.
DR   PIR; I56039; I56039.
DR   HSSP; P10315; 1HSB.
DR   SMR; P16188; 25-299.
DR   IntAct; P16188; -.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P16188; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
DR   GO; GO:0032393; F:MHC class I receptor activity; NAS:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-30 alpha chain.
FT                                /FTId=PRO_0000018822.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT      21     21       H -> Q (in allele A*3002, allele A*3004
FT                                and allele A*3008).
FT                                /FTId=VAR_004366.
FT   VARIANT      33     33       S -> Y (in allele A*3008).
FT                                /FTId=VAR_010284.
FT   VARIANT      55     55       T -> A (in allele A*3006).
FT                                /FTId=VAR_016653.
FT   VARIANT      80     80       R -> G (in allele A*3003).
FT                                /FTId=VAR_004367.
FT   VARIANT      86     86       Q -> E (in allele A*3007).
FT                                /FTId=VAR_016738.
FT   VARIANT      89     90       RN -> GK (in allele A*3007).
FT                                /FTId=VAR_016739.
FT   VARIANT      94     94       Q -> H (in allele A*3002, allele A*3003,
FT                                allele A*3004, allele A*3006 and allele
FT                                A*3007).
FT                                /FTId=VAR_004368.
FT   VARIANT     100    101       VD -> EN (in allele A*3002, allele
FT                                A*3003, allele A*3004, allele A*3006 and
FT                                allele A*3007).
FT                                /FTId=VAR_004369.
FT   VARIANT     175    176       RW -> HV (in allele A*3004 and allele
FT                                A*3006).
FT                                /FTId=VAR_004370.
FT   VARIANT     176    176       W -> R (in allele A*3002, allele A*3003
FT                                and allele A*3007).
FT                                /FTId=VAR_004371.
FT   VARIANT     180    180       L -> W (in allele A*3004 and allele
FT                                A*3006).
FT                                /FTId=VAR_004372.
FT   CONFLICT     33     33       S -> F (in Ref. 1).
SQ   SEQUENCE   365 AA;  40905 MW;  521166D95FB1DC28 CRC64;
     MAVMAPRTLL LLLSGALALT HTWAGSHSMR YFSTSVSRPG SGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQER PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEAGSHTIQ
     IMYGCDVGSD GRFLRGYEQH AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARWAEQL
     RAYLEGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
     SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL
     TACKV
//
ID   1A31_HUMAN              Reviewed;         365 AA.
AC   P16189; O62924; O98009; O98137; Q8MHM1; Q9TPQ3; Q9TQ24; Q9UQU6;
AC   Q9UQU7;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 2.
DT   01-MAY-2007, entry version 67.
DE   HLA class I histocompatibility antigen, A-31 alpha chain precursor
DE   (MHC class I antigen A*31).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*3101).
RX   MEDLINE=90038496; PubMed=2478623;
RA   Kato K., Trapani J.A., Allopenna J., Dupont B., Yang S.Y.;
RT   "Molecular analysis of the serologically defined HLA-Aw19 antigens. A
RT   genetically distinct family of HLA-A antigens comprising A29, A31,
RT   A32, and Aw33, but probably not A30.";
RL   J. Immunol. 143:3371-3378(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*3101).
RX   MEDLINE=92269955; PubMed=1317015; DOI=10.1038/357326a0;
RA   Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J.,
RA   Williams R.C., Luz R., Petzl-Erler M.L., Parham P.;
RT   "Unusual HLA-B alleles in two tribes of Brazilian Indians.";
RL   Nature 357:326-329(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*3101).
RX   MEDLINE=96387675; PubMed=8795145;
RA   Arnett K.L., Adams E.J., Parham P.;
RT   "On the sequence of A*3101.";
RL   Tissue Antigens 47:428-430(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE OF 9-365 (ALLELE A*3101).
RX   MEDLINE=92269956; PubMed=1589035; DOI=10.1038/357329a0;
RA   Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L.,
RA   Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H.,
RA   Troup G.M., Hughes A.L., Letvin N.L.;
RT   "New recombinant HLA-B alleles in a tribe of South American
RT   Amerindians indicate rapid evolution of MHC class I loci.";
RL   Nature 357:329-333(1992).
RN   [5]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*3104).
RA   Bettinotti M.P., Dhillon G., Hackett J., Simonis T.B., Marincola F.M.;
RT   "A new HLA-A*31 allele.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*3103).
RA   Bunce M., Dunn P., Ross J.;
RT   "Characterization of two new HLA-A alleles identified by PCR-SSP.";
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*3104).
RA   Mitsuishi Y.;
RT   "New HLA-A31 allele identified in African American population.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*3102).
RA   Dunn P.P.;
RT   "Characterization of an HLA-A*31 variant.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*3105).
RA   Juji T., Akesaka T., Kashiwase K., Ishikawa Y.;
RT   "HLA-A31012V1.";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*3102).
RX   MEDLINE=21160440; PubMed=11260503;
RX   DOI=10.1034/j.1399-0039.2001.057002095.x;
RA   Hickman H.D., Cavett J.W., Ellexson-Turner M.E., Sparkman J.N.,
RA   Bennett T.T., Turner S., Sidebottom D.A., Trachtenberg E.A.,
RA   Confer D.L., Hildebrand W.H.;
RT   "Non-conservative substitutions distinguish previously uncharacterized
RT   HLA-A molecules.";
RL   Tissue Antigens 57:95-102(2001).
RN   [11]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*3106).
RC   TISSUE=Blood;
RA   Anholts J.D.H.;
RT   "Four new HLA alleles found, and confirmation of DRB1*0322, DRB1*1433
RT   and A*3106.";
RL   Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-31 are known: A*3101,
CC       A*3102, A*3103, A*3104, A*3105 (A3101v1) and A*3106. The sequence
CC       shown is that of A*3101.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; M30578; AAA59613.1; -; Genomic_DNA.
DR   EMBL; M84375; AAA59599.1; -; mRNA.
DR   EMBL; L78918; AAB05976.1; -; Genomic_DNA.
DR   EMBL; AF148863; AAD39981.1; -; Genomic_DNA.
DR   EMBL; AF067439; AAC18859.1; -; Genomic_DNA.
DR   EMBL; AF067438; AAC18859.1; JOINED; Genomic_DNA.
DR   EMBL; AF105028; AAC79721.1; -; Genomic_DNA.
DR   EMBL; AF105027; AAC79721.1; JOINED; Genomic_DNA.
DR   EMBL; AJ239045; CAB43109.1; -; Genomic_DNA.
DR   EMBL; AJ239046; CAB43110.1; -; Genomic_DNA.
DR   EMBL; AB032597; BAA84645.1; -; Genomic_DNA.
DR   EMBL; AF041370; AAD02207.1; -; Genomic_DNA.
DR   EMBL; AF041369; AAD02207.1; JOINED; Genomic_DNA.
DR   EMBL; AJ506789; CAD44950.1; -; Genomic_DNA.
DR   EMBL; AJ506790; CAD44950.1; JOINED; Genomic_DNA.
DR   PIR; I72170; I72170.
DR   UniGene; Hs.181244; -.
DR   HSSP; P10315; 1HSB.
DR   SMR; P16189; 25-299.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P16189; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-31 alpha chain.
FT                                /FTId=PRO_0000018823.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT      90     90       N -> K (in allele A*3102).
FT                                /FTId=VAR_016348.
FT   VARIANT     114    114       A -> D (in allele A*3103).
FT                                /FTId=VAR_016349.
FT   VARIANT     121    121       M -> I (in allele A*3103 and allele
FT                                A*3104).
FT                                /FTId=VAR_010373.
FT   VARIANT     138    138       Q -> R (in allele A*3103, allele A*3104
FT                                and allele A*3106).
FT                                /FTId=VAR_010374.
FT   VARIANT     190    191       EW -> DG (in allele A*3105).
FT                                /FTId=VAR_016350.
SQ   SEQUENCE   365 AA;  41004 MW;  4E760C821A3C553B CRC64;
     MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQER PEYWDQETRN VKAHSQIDRV DLGTLRGYYN QSEAGSHTIQ
     MMYGCDVGSD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL
     RAYLEGTCVE WLRRYLENGK ETLQRTDPPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL
     TACKV
//
ID   1A32_HUMAN              Reviewed;         365 AA.
AC   P10314; O77937; Q29838; Q8MHN9; Q9MYE9; Q9MYG5; Q9TQF5; Q9TQF9;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   01-MAY-2007, entry version 68.
DE   HLA class I histocompatibility antigen, A-32 alpha chain precursor
DE   (MHC class I antigen A*32).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*3201).
RA   Domena J.D.;
RL   Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 25-298 (ALLELE A*3201).
RX   MEDLINE=87058961; PubMed=2431040;
RA   Wan A.M., Ennis P., Parham P., Holmes N.;
RT   "The primary structure of HLA-A32 suggests a region involved in
RT   formation of the Bw4/Bw6 epitopes.";
RL   J. Immunol. 137:3671-3674(1986).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*3202).
RC   TISSUE=Blood;
RX   MEDLINE=97045038; PubMed=8881042; DOI=10.1007/s002510050171;
RA   Zino E., Severini G.M., Mazzi B., Bordignon C., Benazzi E.,
RA   Fleischhauer K.;
RT   "Sequencing of a new HLA-A*32 subtype (A*3202).";
RL   Immunogenetics 45:76-77(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*3203 AND A*3204).
RX   MEDLINE=20309230; PubMed=10852390;
RX   DOI=10.1034/j.1399-0039.2000.550412.x;
RA   Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R.,
RA   Ng J., Hartzman R.J., Hurley C.K.;
RT   "Seventeen more novel HLA-A locus alleles.";
RL   Tissue Antigens 55:369-373(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*3203).
RA   Kanaan C., Hepner J., Thornton A.;
RT   "Confirmatory exon 2 and 3 sequence for HLA-A*3203.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*3205).
RA   Bettinotti M.P., Hadzikadic L., Adams S., Marincola F.M.;
RT   "A new HLA A-32 allele.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*3206).
RA   Jones P.F., Hurley C.K.;
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-32 are known: A*3201,
CC       A*3202, A*3203, A*3204, A*3205 and A*3206. The sequence shown is
CC       that of A*3201.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; U03907; AAA03605.1; -; mRNA.
DR   EMBL; X97120; CAA65786.1; -; mRNA.
DR   EMBL; AF072762; AAC26020.1; -; Genomic_DNA.
DR   EMBL; AF072761; AAC26020.1; JOINED; Genomic_DNA.
DR   EMBL; AF137078; AAD33738.1; -; Genomic_DNA.
DR   EMBL; AF137077; AAD33738.1; JOINED; Genomic_DNA.
DR   EMBL; AF139892; AAD33849.1; -; Genomic_DNA.
DR   EMBL; AF139891; AAD33849.1; JOINED; Genomic_DNA.
DR   EMBL; AF517562; AAM78538.1; -; Genomic_DNA.
DR   EMBL; AF517561; AAM78538.1; JOINED; Genomic_DNA.
DR   EMBL; AF217560; AAF28733.1; -; mRNA.
DR   EMBL; AF226837; AAF29554.1; -; Genomic_DNA.
DR   EMBL; AF226836; AAF29554.1; JOINED; Genomic_DNA.
DR   PIR; A26088; HLHU32.
DR   UniGene; Hs.181244; -.
DR   HSSP; P10315; 1HSB.
DR   SMR; P10314; 25-299.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P10314; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-32 alpha chain.
FT                                /FTId=PRO_0000018824.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT      89     90       RN -> GK (in allele A*3205).
FT                                /FTId=VAR_016656.
FT   VARIANT     101    101       S -> N (in allele A*3203).
FT                                /FTId=VAR_016657.
FT   VARIANT     121    121       M -> I (in allele A*3204).
FT                                /FTId=VAR_016831.
FT   VARIANT     129    129       P -> S (in allele A*3204).
FT                                /FTId=VAR_016832.
FT   VARIANT     133    133       L -> F (in allele A*3204).
FT                                /FTId=VAR_016833.
FT   VARIANT     138    138       Q -> R (in allele A*3204).
FT                                /FTId=VAR_016834.
FT   VARIANT     168    168       Q -> K (in allele A*3204).
FT                                /FTId=VAR_016835.
FT   VARIANT     175    175       R -> H (in allele A*3202, allele A*3204
FT                                and allele A*3206).
FT                                /FTId=VAR_004373.
FT   VARIANT     176    176       V -> E (in allele A*3204).
FT                                /FTId=VAR_016836.
FT   VARIANT     180    180       L -> Q (in allele A*3202).
FT                                /FTId=VAR_004374.
FT   VARIANT     185    185       E -> D (in allele A*3204).
FT                                /FTId=VAR_016837.
SQ   SEQUENCE   365 AA;  41048 MW;  BF7AF225329E0319 CRC64;
     MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAHSQTDRE SLRIALRYYN QSEAGSHTIQ
     MMYGCDVGPD GRLLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL
     RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA MFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL
     TACKV
//
ID   1A33_HUMAN              Reviewed;         365 AA.
AC   P16190; O02939; O02954;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 3.
DT   01-MAY-2007, entry version 68.
DE   HLA class I histocompatibility antigen, A-33 alpha chain precursor
DE   (MHC class I antigen A*33) (Aw-33) (Aw-19).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*3301).
RX   MEDLINE=90038496; PubMed=2478623;
RA   Kato K., Trapani J.A., Allopenna J., Dupont B., Yang S.Y.;
RT   "Molecular analysis of the serologically defined HLA-Aw19 antigens. A
RT   genetically distinct family of HLA-A antigens comprising A29, A31,
RT   A32, and Aw33, but probably not A30.";
RL   J. Immunol. 143:3371-3378(1989).
RN   [2]
RP   SEQUENCE REVISION TO 178-179; 210 AND 345.
RA   Yang S.Y.;
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*3301).
RA   Szmania S., Baxter-Lowe L.A.;
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*3302).
RX   MEDLINE=93369838; PubMed=8362415;
RA   Kato N., Kikuchi A., Kano K., Egawa K., Takiguchi M.;
RT   "Molecular analysis of a novel HLA-A33 subtype associated with HLA-
RT   B44.";
RL   Tissue Antigens 41:211-213(1993).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*3303).
RX   MEDLINE=95242316; PubMed=7725315;
RA   Balas A., Garcia-Sanchez F., Vicario J.L.;
RT   "Molecular characterization of a novel HLA-A33 allele (A*3303).";
RL   Tissue Antigens 45:73-76(1995).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-99 AND 122-205 (ALLELES A*3301
RP   AND A*3303).
RX   MEDLINE=95381237; PubMed=7652743;
RA   Blasczyk R., Wehling J., Hahn U., Schwella N., Huhn D., Salama A.;
RT   "Identification of a novel HLA-A33 subtype (A*3303) and correction of
RT   the A*3301 sequence.";
RL   Tissue Antigens 45:348-352(1995).
RN   [7]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*3301 AND A*3303).
RA   Gao X., Jakobsen I., Serjeantson S.W.;
RL   Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-33 are known: A*3301 (Aw-
CC       33.1), A*3302 and A*3303. The sequence shown is that of A*3301.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; M30580; AAB47870.1; -; Genomic_DNA.
DR   EMBL; U83416; AAB53374.1; -; mRNA.
DR   EMBL; L06440; AAA71914.1; -; mRNA.
DR   EMBL; U09740; AAA79865.1; -; mRNA.
DR   EMBL; X83004; CAA58125.1; -; Genomic_DNA.
DR   EMBL; X83005; CAA58126.1; -; Genomic_DNA.
DR   EMBL; X83002; CAA58123.1; -; Genomic_DNA.
DR   EMBL; X83003; CAA58124.1; -; Genomic_DNA.
DR   EMBL; U19735; AAB60652.1; -; Genomic_DNA.
DR   EMBL; U19736; AAB60653.1; -; Genomic_DNA.
DR   PIR; I38610; I38610.
DR   PIR; S51099; S51099.
DR   PIR; S51100; S51100.
DR   HSSP; P10315; 1HSB.
DR   SMR; P16190; 25-299.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P16190; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-33 alpha chain.
FT                                /FTId=PRO_0000018825.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT      41     41       R -> S (in allele A*3302).
FT                                /FTId=VAR_004375.
FT   VARIANT     195    195       H -> Y (in allele A*3302 and allele
FT                                A*3303).
FT                                /FTId=VAR_004376.
FT   VARIANT     217    218       AV -> PI (in allele A*3302).
FT                                /FTId=VAR_004377.
FT   VARIANT     358    358       M -> V (in allele A*3302).
FT                                /FTId=VAR_004378.
FT   CONFLICT    210    210       K -> R (in Ref. 3).
SQ   SEQUENCE   365 AA;  40892 MW;  060AE508EADEB328 CRC64;
     MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQIDRV DLGTLRGYYN QSEAGSHTIQ
     MMYGCDVGSD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL
     RAYLEGTCVE WLRRHLENGK ETLQRTDPPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL
     TACKV
//
ID   1A34_HUMAN              Reviewed;         365 AA.
AC   P30453; P30454;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 61.
DE   HLA class I histocompatibility antigen, A-34 alpha chain precursor
DE   (MHC class I antigen A*34) (Aw-34) (A-10).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*3401 AND A*3402).
RX   MEDLINE=93056508; PubMed=1431115;
RA   Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J.,
RA   Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L.,
RA   Martell R.W., du Toit E.D., Parham P.;
RT   "Distinctive HLA-A,B antigens of black populations formed by
RT   interallelic conversion.";
RL   J. Immunol. 149:3411-3415(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*3401 AND A*3402).
RX   MEDLINE=93235211; PubMed=8475492;
RA   Madrigal J.A., Hildebrand W.H., Belich M.P., Benjamin R.J.,
RA   Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L.,
RA   du Toit E.D., Parham P.;
RT   "Structural diversity in the HLA-A10 family of alleles: correlations
RT   with serology.";
RL   Tissue Antigens 41:72-80(1993).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-34 are known: A*3401 (Aw-
CC       34.1) and A*3402 (Aw-34.2). The sequence shown is that of A*3401.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X61704; CAA43873.1; -; mRNA.
DR   EMBL; X61705; CAA43874.1; -; mRNA.
DR   PIR; I37477; I37477.
DR   PIR; I37483; I37483.
DR   UniGene; Hs.181244; -.
DR   HSSP; P10315; 1HSB.
DR   SMR; P30453; 25-299.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P30453; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-34 alpha chain.
FT                                /FTId=PRO_0000018826.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT       3      3       I -> V (in allele A*3402).
FT                                /FTId=VAR_004379.
FT   VARIANT      90     90       K -> N (in allele A*3402).
FT                                /FTId=VAR_004380.
FT   VARIANT     121    121       R -> I (in allele A*3402).
FT                                /FTId=VAR_004381.
FT   VARIANT     129    129       P -> S (in allele A*3402).
FT                                /FTId=VAR_004382.
FT   VARIANT     138    138       Q -> R (in allele A*3402).
FT                                /FTId=VAR_004383.
FT   VARIANT     180    180       W -> L (in allele A*3402).
FT                                /FTId=VAR_004384.
FT   VARIANT     312    312       L -> I (in allele A*3402).
FT                                /FTId=VAR_004385.
SQ   SEQUENCE   365 AA;  41055 MW;  063BF63E6E6E01F6 CRC64;
     MAIMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDRNTRK VKAQSQTDRV DLGTLRGYYN QSEDGSHTIQ
     RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW
     RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG ILAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDMSL
     TACKV
//
ID   1A36_HUMAN              Reviewed;         365 AA.
AC   P30455; Q9MY89;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 60.
DE   HLA class I histocompatibility antigen, A-36 alpha chain precursor
DE   (MHC class I antigen A*36) (Aw-36).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*3601).
RX   MEDLINE=93056508; PubMed=1431115;
RA   Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J.,
RA   Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L.,
RA   Martell R.W., du Toit E.D., Parham P.;
RT   "Distinctive HLA-A,B antigens of black populations formed by
RT   interallelic conversion.";
RL   J. Immunol. 149:3411-3415(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*3602).
RA   Rizzuto G.A., Hurley C.K.;
RT   "Novel HLA-A Allele.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- INTERACTION:
CC       P30457:HLA-A; NbExp=1; IntAct=EBI-1050524, EBI-1049899;
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-36 are known: A*3601 and
CC       A*3602. The sequence shown is that of A*3601.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X61700; CAA43869.1; -; mRNA.
DR   EMBL; AF274505; AAF78082.1; -; Genomic_DNA.
DR   EMBL; AF274504; AAF78082.1; JOINED; Genomic_DNA.
DR   PIR; I37478; I37478.
DR   UniGene; Hs.181244; -.
DR   HSSP; P10315; 1HSB.
DR   SMR; P30455; 25-298.
DR   IntAct; P30455; -.
DR   Ensembl; ENSG00000206441; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   GO; GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
DR   GO; GO:0032393; F:MHC class I receptor activity; NAS:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-36 alpha chain.
FT                                /FTId=PRO_0000018827.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT     182    182       V -> A (in allele A*3602).
FT                                /FTId=VAR_016610.
FT   VARIANT     185    185       E -> D (in allele A*3602).
FT                                /FTId=VAR_016611.
SQ   SEQUENCE   365 AA;  40934 MW;  BA00A0085989CD3E CRC64;
     MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ
     IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAVHAAEQR
     RVYLEGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
     SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL
     TACKV
//
ID   1A43_HUMAN              Reviewed;         365 AA.
AC   P30456; O19509;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 61.
DE   HLA class I histocompatibility antigen, A-43 alpha chain precursor
DE   (MHC class I antigen A*43) (Aw-43).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*4301).
RX   MEDLINE=93056508; PubMed=1431115;
RA   Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J.,
RA   Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L.,
RA   Martell R.W., du Toit E.D., Parham P.;
RT   "Distinctive HLA-A,B antigens of black populations formed by
RT   interallelic conversion.";
RL   J. Immunol. 149:3411-3415(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*4301).
RX   MEDLINE=93235211; PubMed=8475492;
RA   Madrigal J.A., Hildebrand W.H., Belich M.P., Benjamin R.J.,
RA   Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L.,
RA   du Toit E.D., Parham P.;
RT   "Structural diversity in the HLA-A10 family of alleles: correlations
RT   with serology.";
RL   Tissue Antigens 41:72-80(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*4301).
RX   MEDLINE=99446859; PubMed=10519370;
RX   DOI=10.1034/j.1399-0039.1999.540314.x;
RA   Bei M., Ng J., Slack R., Ellis J., Hartzman R.J., Hurley C.K.;
RT   "The relative frequencies of HLA-A*10 alleles in five major United
RT   States ethnic populations.";
RL   Tissue Antigens 54:295-299(1999).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The only allele of A-43 known is A*4301 which is
CC       shown here.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X61703; CAA43872.1; -; mRNA.
DR   EMBL; AF008306; AAB65408.1; -; Genomic_DNA.
DR   EMBL; AF008305; AAB65408.1; JOINED; Genomic_DNA.
DR   PIR; I72171; I72171.
DR   UniGene; Hs.181244; -.
DR   HSSP; P10315; 1HSB.
DR   SMR; P30456; 25-299.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P30456; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-43 alpha chain.
FT                                /FTId=PRO_0000018828.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   365 AA;  41033 MW;  213FC69745FB4B0B CRC64;
     MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ
     RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW
     RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDMSL
     TACKV
//
ID   1A66_HUMAN              Reviewed;         365 AA.
AC   P30457; P30458;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 64.
DE   HLA class I histocompatibility antigen, A-66 alpha chain precursor
DE   (MHC class I antigen A*66) (Aw-66) (A-10).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELES A*6601 AND A*6602).
RX   MEDLINE=92044300; PubMed=1940790; DOI=10.1084/jem.174.5.1085;
RA   Madrigal J., Belich M.P., Benjamin R.J., Little A.-M.,
RA   Hildebrand W.H., Mann D.L., Parham P.;
RT   "Molecular definition of a polymorphic antigen (LA45) of free HLA-A
RT   and -B heavy chains found on the surfaces of activated B and T
RT   cells.";
RL   J. Exp. Med. 174:1085-1095(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*6602).
RX   MEDLINE=90237739; PubMed=2139695; DOI=10.1084/jem.171.5.1431;
RA   Schnabl E., Stockinger H., Majdic O., Gaugitsch H., Lindley I.J.D.,
RA   Maurer D., Hajek-Rosenmayr A., Knapp W.;
RT   "Activated human T lymphocytes express MHC class I heavy chains not
RT   associated with beta 2-microglobulin.";
RL   J. Exp. Med. 171:1431-1442(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-322 (ALLELE A*6601).
RA   Hurley C., Bei M.;
RL   Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- INTERACTION:
CC       P16188:HLA-A; NbExp=1; IntAct=EBI-1049899, EBI-1044129;
CC       P30455:HLA-A; NbExp=1; IntAct=EBI-1049899, EBI-1050524;
CC       Q860B5:HLA-A; NbExp=1; IntAct=EBI-1049899, EBI-1053495;
CC       Q9MYE6:HLA-A; NbExp=1; IntAct=EBI-1049899, EBI-1050350;
CC       Q53QP2:UGCGL1; NbExp=1; IntAct=EBI-1049899, EBI-1056389;
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-66 are known: A*6601 and
CC       A*6602 (Aw67). The sequence shown is that of A*6601.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X61711; CAA43880.1; -; mRNA.
DR   EMBL; X61712; CAA43881.1; -; mRNA.
DR   EMBL; X51745; CAA36034.1; -; mRNA.
DR   EMBL; U17571; AAA56781.1; -; mRNA.
DR   PIR; JL0135; JL0135.
DR   UniGene; Hs.181244; -.
DR   HSSP; P10315; 1HSB.
DR   SMR; P30457; 25-299.
DR   IntAct; P30457; -.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P30457; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-66 alpha chain.
FT                                /FTId=PRO_0000018829.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT      28     28       S -> W (in allele A*6602).
FT                                /FTId=VAR_004386.
FT   VARIANT     114    114       D -> A (in allele A*6602).
FT                                /FTId=VAR_004387.
FT   VARIANT     187    187       R -> E (in allele A*6602; requires 2
FT                                nucleotide substitutions).
FT                                /FTId=VAR_004388.
SQ   SEQUENCE   365 AA;  41082 MW;  A3272DBE4008328D CRC64;
     MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAQSQTDRV DLGTLRGYYN QSEDGSHTIQ
     RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW
     RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDMSL
     TACKV
//
ID   1A68_HUMAN              Reviewed;         365 AA.
AC   P01891; O19673; O19695; O19794; O19795; O43907; O77938; O98010;
AC   P10315; P79505; Q9MYA5; Q9MYC4; Q9TQG7; Q9TQN5; Q9UIN2;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2001, sequence version 4.
DT   01-MAY-2007, entry version 82.
DE   HLA class I histocompatibility antigen, A-68 alpha chain precursor
DE   (MHC class I antigen A*68) (Aw-68) (A-28).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*6802).
RX   MEDLINE=87252273; PubMed=3496393;
RA   Holmes N., Ennis P., Wan A.M., Denney D.W., Parham P.;
RT   "Multiple genetic mechanisms have contributed to the generation of the
RT   HLA-A2/A28 family of class I MHC molecules.";
RL   J. Immunol. 139:936-941(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*6802).
RA   Domena J.D.;
RL   Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*6803).
RX   MEDLINE=97045039; PubMed=8881043; DOI=10.1007/s002510050172;
RA   Ellexson M., Lau M., Terasaki P., Hildebrand W.H.;
RT   "Molecular characterization of HLA-A*6803.";
RL   Immunogenetics 45:78-79(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*6808).
RX   MEDLINE=99321037; PubMed=10395114;
RX   DOI=10.1034/j.1399-0039.1999.530614.x;
RA   Cox S.T., Arguello J.R., Marsh S.G.E., Boham E., Lau M., Kwan P.L.,
RA   Madrigal J.A., Little A.-M.;
RT   "Sequence of HLA-A*6808.";
RL   Tissue Antigens 53:597-600(1999).
RN   [5]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*68011).
RC   TISSUE=Blood;
RA   Cox S.T.;
RT   "Confirmation of HLA-A*68011.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*6817).
RX   MEDLINE=20340076; PubMed=10885567;
RX   DOI=10.1034/j.1399-0039.2000.550509.x;
RA   Ramon D., Scott I., Cox S.T., Pesoa S., Vullo C., Little A.M.,
RA   Madrigal J.A.;
RT   "HLA-A*6817, identified in the Kolla Amerindians of north-west
RT   Argentina possesses a novel nucleotide substitution.";
RL   Tissue Antigens 55:453-454(2000).
RN   [7]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*6806).
RA   Bei M., Hurley C.K.;
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*6803).
RC   TISSUE=Blood;
RX   MEDLINE=97419180; PubMed=9271640; DOI=10.1007/s002510050304;
RA   Vargas-Alarcon G., Martinez-Laso J., Gomez-Casado E., Perez-Blas M.,
RA   Granados J., Alegre R., Alvarez M., Zuniga J., Arnaiz-Villena A.;
RT   "Description of HLA-A*6803 and A*68N in Mazatecan Indians from
RT   Mexico.";
RL   Immunogenetics 46:446-447(1997).
RN   [9]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*6803).
RC   TISSUE=Blood;
RA   Blasczyk R.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*6802).
RA   Edson S.M., Hurley C.K.;
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [11]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*6809 AND A*6810).
RX   MEDLINE=20309230; PubMed=10852390;
RX   DOI=10.1034/j.1399-0039.2000.550412.x;
RA   Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R.,
RA   Ng J., Hartzman R.J., Hurley C.K.;
RT   "Seventeen more novel HLA-A locus alleles.";
RL   Tissue Antigens 55:369-373(2000).
RN   [12]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-206 (ALLELE A*6816).
RX   MEDLINE=20260982; PubMed=10803837; DOI=10.1007/s002510050618;
RA   Gomez-Casado E., Martinez-Laso J., Gonzalez-Hevilla M., Longas J.,
RA   Rubio I., Silvera-Redondo C., Garcia-Gomez A., Lowy E.,
RA   Arnaiz-Villena A.;
RT   "A novel HLA-A*6816 allele possible generated by a point mutation in a
RT   Chilean from Punta Arenas (Magellan Strait).";
RL   Immunogenetics 51:257-260(2000).
RN   [13]
RP   NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*6807 AND A*6817).
RX   MEDLINE=21160440; PubMed=11260503;
RX   DOI=10.1034/j.1399-0039.2001.057002095.x;
RA   Hickman H.D., Cavett J.W., Ellexson-Turner M.E., Sparkman J.N.,
RA   Bennett T.T., Turner S., Sidebottom D.A., Trachtenberg E.A.,
RA   Confer D.L., Hildebrand W.H.;
RT   "Non-conservative substitutions distinguish previously uncharacterized
RT   HLA-A molecules.";
RL   Tissue Antigens 57:95-102(2001).
RN   [14]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-297 (ALLELE A*6801).
RX   MEDLINE=86055720; PubMed=3877632;
RA   Holmes N., Parham P.;
RT   "Exon shuffling in vivo can generate novel HLA class I molecules.";
RL   EMBO J. 4:2849-2854(1985).
RN   [15]
RP   PARTIAL PROTEIN SEQUENCE OF 25-294 (A*6801).
RX   MEDLINE=82247941; PubMed=6179086;
RA   Lopez de Castro J.A., Strominger J.L., Strong D.M., Orr H.T.;
RT   "Structure of crossreactive human histocompatibility antigens HLA-A28
RT   and HLA-A2: possible implications for the generation of HLA
RT   polymorphism.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:3813-3817(1982).
RN   [16]
RP   X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 25-294 (A*6801).
RX   MEDLINE=93078854; PubMed=1448153; DOI=10.1038/360364a0;
RA   Guo H.-C., Jardetzky T.S., Garrett T.P.J., Lane W.S., Strominger J.L.,
RA   Wiley D.C.;
RT   "Different length peptides bind to HLA-Aw68 similarly at their ends
RT   but bulge out in the middle.";
RL   Nature 360:364-366(1992).
RN   [17]
RP   X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 25-294 (A*6801).
RX   MEDLINE=93078855; PubMed=1448154; DOI=10.1038/360367a0;
RA   Silver M.L., Guo H.-C., Strominger J.L., Wiley D.C.;
RT   "Atomic structure of a human MHC molecule presenting an influenza
RT   virus peptide.";
RL   Nature 360:367-369(1992).
RN   [18]
RP   X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 25-199 (A*6801).
RX   MEDLINE=95166800; PubMed=7862664;
RA   Collins E.J., Garboczi D.N., Karpusas M.N., Wiley D.C.;
RT   "The three-dimensional structure of a class I major histocompatibility
RT   complex molecule missing the alpha 3 domain of the heavy chain.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:1218-1221(1995).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-68 are known: A*6801
CC       (Aw68.1), A*6802, A*6803. A*6804, A*6805, A*6806, A*6807, A*6808,
CC       A*6809, A*6810, A*6816 and A*6817. The sequence shown is that of
CC       A*6801.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; U03861; AAA03602.1; -; Unassigned_DNA.
DR   EMBL; X03070; CAB56605.1; -; Genomic_DNA.
DR   EMBL; X03071; CAB56606.1; -; Genomic_DNA.
DR   EMBL; U41057; AAB41292.1; -; mRNA.
DR   EMBL; AJ315642; CAC44382.1; -; Genomic_DNA.
DR   EMBL; AF144013; AAF74211.1; -; Genomic_DNA.
DR   EMBL; AJ245567; CAB59722.1; -; Genomic_DNA.
DR   EMBL; U91628; AAB50567.1; -; Genomic_DNA.
DR   EMBL; U91627; AAB50567.1; JOINED; Genomic_DNA.
DR   EMBL; U89946; AAB82079.1; -; Genomic_DNA.
DR   EMBL; U89947; AAB82080.1; -; Genomic_DNA.
DR   EMBL; AJ001274; CAA04647.1; -; mRNA.
DR   EMBL; AF072770; AAC25782.1; -; Genomic_DNA.
DR   EMBL; AF072769; AAC25782.1; JOINED; Genomic_DNA.
DR   EMBL; AF135545; AAD22270.1; -; Genomic_DNA.
DR   EMBL; AF135544; AAD22270.1; JOINED; Genomic_DNA.
DR   EMBL; AF108431; AAD27539.1; -; Genomic_DNA.
DR   EMBL; AF108430; AAD27539.1; JOINED; Genomic_DNA.
DR   EMBL; AJ223972; CAA11708.1; -; Genomic_DNA.
DR   EMBL; AF041372; AAD02208.1; -; Genomic_DNA.
DR   EMBL; AF041371; AAD02208.1; JOINED; Genomic_DNA.
DR   EMBL; AF268398; AAF73477.1; -; Genomic_DNA.
DR   EMBL; AF268397; AAF73477.1; JOINED; Genomic_DNA.
DR   UniGene; Hs.181244; -.
DR   PDB; 1HSB; X-ray; A=25-294.
DR   PDB; 1TMC; X-ray; A=25-199.
DR   PDB; 2HLA; X-ray; A=25-294.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   LinkHub; P01891; -.
DR   ArrayExpress; P01891; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   3D-structure; Direct protein sequencing; Glycoprotein;
KW   Host-virus interaction; Immune response; Membrane; MHC I;
KW   Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-68 alpha chain.
FT                                /FTId=PRO_0000018830.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...).
FT   DISULFID    125    188
FT   DISULFID    227    283
FT   VARIANT      36     36       V -> M (in allele A*6802).
FT                                /FTId=VAR_004389.
FT   VARIANT      86     87       RN -> EE (in allele A*6810).
FT                                /FTId=VAR_010362.
FT   VARIANT      94     94       Q -> H (in allele A*6803, allele A*6804
FT                                and allele A*6805).
FT                                /FTId=VAR_010363.
FT   VARIANT      97     97       T -> I (in allele A*6804).
FT                                /FTId=VAR_010364.
FT   VARIANT      98     98       D -> H (in allele A*6805).
FT                                /FTId=VAR_010365.
FT   VARIANT     121    121       M -> R (in allele A*6802).
FT                                /FTId=VAR_004390.
FT   VARIANT     129    129       S -> P (in allele A*6802).
FT                                /FTId=VAR_004391.
FT   VARIANT     138    138       R -> E (in allele A*6806; requires 2
FT                                nucleotide substitutions).
FT                                /FTId=VAR_010366.
FT   VARIANT     138    138       R -> H (in allele A*6802).
FT                                /FTId=VAR_004392.
FT   VARIANT     140    140       D -> H (in allele A*6806 and allele
FT                                A*6807).
FT                                /FTId=VAR_010367.
FT   VARIANT     140    140       D -> V (in allele A*6817).
FT                                /FTId=VAR_010368.
FT   VARIANT     140    140       D -> Y (in allele A*6802).
FT                                /FTId=VAR_004393.
FT   VARIANT     175    175       H -> L (in allele A*6816).
FT                                /FTId=VAR_010369.
FT   VARIANT     180    180       W -> L (in allele A*6808).
FT                                /FTId=VAR_010370.
FT   VARIANT     180    180       W -> Q (in allele A*6809; requires 2
FT                                nucleotide substitutions).
FT                                /FTId=VAR_010371.
FT   CONFLICT    206    206       T -> A (in Ref. 12).
FT   CONFLICT    231    231       S -> G (in Ref. 15).
FT   STRAND       27     36
FT   STRAND       41     43
FT   STRAND       45     52
FT   STRAND       55     61
FT   STRAND       64     66
FT   HELIX        74     76
FT   HELIX        81    108
FT   STRAND      118    127
FT   STRAND      133    142
FT   STRAND      145    150
FT   STRAND      157    161
FT   HELIX       162    173
FT   HELIX       176    185
FT   HELIX       187    198
FT   HELIX       200    203
FT   STRAND      210    235
FT   STRAND      238    243
FT   STRAND      246    248
FT   STRAND      252    254
FT   STRAND      261    263
FT   STRAND      265    274
FT   HELIX       278    280
FT   STRAND      281    286
FT   STRAND      290    292
SQ   SEQUENCE   365 AA;  40909 MW;  78539C59DB8B1DFC CRC64;
     MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAQSQTDRV DLGTLRGYYN QSEAGSHTIQ
     MMYGCDVGSD GRFLRGYRQD AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQW
     RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWVA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL
     TACKV
//
ID   1A74_HUMAN              Reviewed;         365 AA.
AC   P30459; O19647; O43906; O46874; Q95IZ5; Q9UIN1;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 62.
DE   HLA class I histocompatibility antigen, A-74 alpha chain precursor
DE   (MHC class I antigen A*74) (Aw-74) (Aw-19).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*7401).
RX   MEDLINE=93056508; PubMed=1431115;
RA   Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J.,
RA   Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L.,
RA   Martell R.W., du Toit E.D., Parham P.;
RT   "Distinctive HLA-A,B antigens of black populations formed by
RT   interallelic conversion.";
RL   J. Immunol. 149:3411-3415(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ALLELE A*7401).
RA   Hurley C.;
RL   Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-206 (ALLELES A*7402 AND A*7403).
RC   TISSUE=Blood;
RX   MEDLINE=97051454; PubMed=8896180;
RA   Blasczyk R., Wehling J., Onaldi-Mohr D., Rebmann V.,
RA   Chandanayingyong D., Grosse-Wilde H.;
RT   "Structural definition of the A*74 group: implications for matching in
RT   bone marrow transplantation with alternative donors.";
RL   Tissue Antigens 48:205-209(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-206 (ALLELE A*7404).
RX   MEDLINE=21108617; PubMed=11169261;
RX   DOI=10.1034/j.1399-0039.2001.057001070.x;
RA   Cox S.T., Mcwhinnie A.J., Koester R.P., Heine U., Holman R.,
RA   Madrigal A.J., Little A.-M.;
RT   "Further diversity at HLA-A and -B loci identified in Afro-Caribbean
RT   potential bone marrow donors.";
RL   Tissue Antigens 57:70-72(2001).
RN   [5]
RP   NUCLEOTIDE SEQUENCE OF 25-206 (ALLELE A*7405).
RX   MEDLINE=21160440; PubMed=11260503;
RX   DOI=10.1034/j.1399-0039.2001.057002095.x;
RA   Hickman H.D., Cavett J.W., Ellexson-Turner M.E., Sparkman J.N.,
RA   Bennett T.T., Turner S., Sidebottom D.A., Trachtenberg E.A.,
RA   Confer D.L., Hildebrand W.H.;
RT   "Non-conservative substitutions distinguish previously uncharacterized
RT   HLA-A molecules.";
RL   Tissue Antigens 57:95-102(2001).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The following alleles of A-74 are known: A*7401
CC       A*7402, A*7403, A*7404 and A*7405. The sequence shown is that of
CC       A*7401.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X61701; CAA43870.1; -; mRNA.
DR   EMBL; U17569; AAA56779.1; -; mRNA.
DR   EMBL; U17570; AAA56780.1; -; mRNA.
DR   EMBL; AJ223060; CAA11063.1; -; mRNA.
DR   EMBL; AJ002678; CAA05681.1; -; mRNA.
DR   EMBL; AJ249370; CAB58124.1; -; Genomic_DNA.
DR   EMBL; AF255721; AAK49188.1; -; Genomic_DNA.
DR   EMBL; AF255720; AAK49188.1; JOINED; Genomic_DNA.
DR   PIR; I37482; I37482.
DR   HSSP; P10315; 1HSB.
DR   SMR; P30459; 25-299.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; P30459; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Polymorphism; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-74 alpha chain.
FT                                /FTId=PRO_0000018831.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
FT   VARIANT      23     23       R -> W (in allele A*7402).
FT                                /FTId=VAR_010375.
FT   VARIANT      86     86       Q -> G (in allele A*7404; requires 2
FT                                nucleotide substitutions).
FT                                /FTId=VAR_016612.
FT   VARIANT      90     90       N -> K (in allele A*7404).
FT                                /FTId=VAR_016613.
FT   VARIANT      97     97       T -> A (in allele A*7405).
FT                                /FTId=VAR_016614.
FT   VARIANT     103    103       G -> A (in allele A*7403).
FT                                /FTId=VAR_016615.
SQ   SEQUENCE   365 AA;  40891 MW;  C94BF2569A852371 CRC64;
     MAVMAPRTLL LLLLGALALT QTRAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAHSQTDRV DLGTLRGYYN QSEAGSHTIQ
     MMYGCDVGPD GRLLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL
     RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA MFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL
     TACKV
//
ID   1A80_HUMAN              Reviewed;         365 AA.
AC   Q09160;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   01-MAY-2007, entry version 58.
DE   HLA class I histocompatibility antigen, A-80 alpha chain precursor
DE   (MHC class I antigen A*80) (Aw-80) (A-1).
GN   Name=HLA-A; Synonyms=HLAA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*8001).
RX   MEDLINE=94245293; PubMed=8188325; DOI=10.1007/BF00176169;
RA   Balas A., Garcia-Sanchez F., Gomez-Reino F., Vicario J.L.;
RT   "Characterization of a new and highly distinguishable HLA-A allele in
RT   a Spanish family.";
RL   Immunogenetics 39:452-452(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*8001).
RX   PubMed=8284791;
RA   Domena J.D., Hildebrand W.H., Bias W.B., Parham P.;
RT   "A sixth family of HLA-A alleles defined by HLA-A*8001.";
RL   Tissue Antigens 42:156-159(1993).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin). Interacts with human herpesvirus 8 MIR1 protein
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- PTM: Polyubiquitinated in a post ER compartment by interaction
CC       with human herpesvirus 8 MIR1 protein. This targets the protein
CC       for rapid degradation via the ubiquitin system (By similarity).
CC   -!- POLYMORPHISM: The only allele of A-80 known is A*8001 which is
CC       shown here.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; U03754; AAC04322.1; -; mRNA.
DR   EMBL; L18898; AAA17012.1; -; mRNA.
DR   PIR; I59638; I38439.
DR   UniGene; Hs.181244; -.
DR   HSSP; P10315; 1HSB.
DR   SMR; Q09160; 25-298.
DR   Ensembl; ENSG00000204632; Homo sapiens.
DR   HGNC; HGNC:4931; HLA-A.
DR   MIM; 142800; gene.
DR   ArrayExpress; Q09160; -.
DR   GermOnline; ENSG00000204632; Homo sapiens.
DR   GO; GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
DR   GO; GO:0032393; F:MHC class I receptor activity; NAS:UniProtKB.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Host-virus interaction; Immune response; Membrane;
KW   MHC I; Signal; Transmembrane; Ubl conjugation.
FT   SIGNAL        1     24
FT   CHAIN        25    365       HLA class I histocompatibility antigen,
FT                                A-80 alpha chain.
FT                                /FTId=PRO_0000018832.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    297       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   365 AA;  40792 MW;  CE1BC1CD60CA8FA8 CRC64;
     MAVMPPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDSQFVQF
     DSDAASQRME PRAPWIEQEE PEYWDEETRN VKAHSQTNRA NLGTLRGYYN QSEDGSHTIQ
     IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAARRAEQL
     RAYLEGECVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGKEKR YTCHVQHEGL PEPLTLRWEP
     SSQPTIPIVG IIAGLVLLGA VIAGAVVAAV MWRKKSSVRK GGSYSQAASS DSAQGSDVSL
     TACKV
//
ID   1B01_GORGO              Reviewed;         362 AA.
AC   P30379;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 45.
DE   Class I histocompatibility antigen, GOGO-B0101 alpha chain precursor.
OS   Gorilla gorilla gorilla (Lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92078860; PubMed=1744581; DOI=10.1084/jem.174.6.1491;
RA   Lawlor D.A., Warren E., Taylor P., Parham P.;
RT   "Gorilla class I major histocompatibility complex alleles: comparison
RT   to human and chimpanzee class I.";
RL   J. Exp. Med. 174:1491-1509(1991).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X60255; CAA42807.1; -; mRNA.
DR   PIR; JH0539; JH0539.
DR   HSSP; Q29961; 1HSA.
DR   SMR; P30379; 25-300.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    362       Class I histocompatibility antigen, GOGO-
FT                                B0101 alpha chain.
FT                                /FTId=PRO_0000018901.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    362       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   362 AA;  40171 MW;  419EEE29817165A4 CRC64;
     MRVTAPRTLL LLLSAALALT ETWAGSHSMR YFDTAVSRPG RGEPRFITVG YVDDTQFVRF
     DSDAASPRME PRAPWIEQEG PEYWDRETQT SKAQAQTDRE NLRIALRYYN QSEAGSHTIQ
     RMFGCDVGPD GRLLRGYSQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL
     RAYLEGTCVE WLRRYLENGR ETLQRADTPK THVTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEER YTCHVQHEGL PKPLTLRWEP
     SSQSTIPIVG IVAGLAVLAV VVIGAVVTAV ICRRKSSGGK GGSYSQAASS DSAQGSDVSL
     TA
//
ID   1B01_PANTR              Reviewed;         359 AA.
AC   P13750;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   01-MAY-2007, entry version 52.
DE   CHLA class I histocompatibility antigen, B-1 alpha chain precursor
DE   (Fragment).
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=89030641; PubMed=2460344;
RA   Mayer W.E., Jonker M., Klein D., Ivanyi P., van Seventer G., Klein J.;
RT   "Nucleotide sequences of chimpanzee MHC class I alleles: evidence for
RT   trans-species mode of evolution.";
RL   EMBO J. 7:2765-2774(1988).
RN   [2]
RP   SEQUENCE REVISION.
RA   Mayer W.;
RL   Submitted (FEB-1989) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X13115; CAA31507.1; -; mRNA.
DR   HSSP; Q29961; 1HSA.
DR   SMR; P13750; 21-294.
DR   KEGG; ptr:450150; -.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL       <1     20       By similarity.
FT   CHAIN        21    359       CHLA class I histocompatibility antigen,
FT                                B-1 alpha chain.
FT                                /FTId=PRO_0000018916.
FT   TOPO_DOM     21    305       Extracellular (Potential).
FT   TRANSMEM    306    329       Potential.
FT   TOPO_DOM    330    359       Cytoplasmic (Potential).
FT   DOMAIN      205    291       Ig-like C1-type.
FT   REGION       21    110       Alpha-1.
FT   REGION      111    202       Alpha-2.
FT   REGION      203    294       Alpha-3.
FT   REGION      295    305       Connecting peptide.
FT   CARBOHYD    106    106       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    121    184       By similarity.
FT   DISULFID    223    279       By similarity.
FT   NON_TER       1      1
SQ   SEQUENCE   359 AA;  40174 MW;  858ACBAF74D6829D CRC64;
     APRTVLLLLS AALALTETWA GSHSMRYFYT SVSRPGRGEP RFITVGYVDD TQFVRFDSDA
     ASPRMEPRAP WIEQEGPEYW DRETRNMKAS AQTDRENLRI ALRYYNQSEA GSHTWQTMYG
     CDMGPDGRLL RGYGQYAYDG KDYIALNEDL SSWTAADTAA QITQRKWEAA REAEQRRAYL
     EGTCVEWLRR YLENGKETLQ RADPPKTHVT HHPISDHEAT LRCWALGFYP AEITLTWQRD
     GEDQTQDTEL VETRPEGDRT FQKWAAVVVP SGEEQRYTCH VQHEGLPKPL TLRWEPSSQS
     TIPIVGIVAG LAVLVVTVAV VAVVAAVMCR RKSSGGKGGS YSQAASSDSA QGSDVSLTA
//
ID   1B01_SAGOE              Reviewed;         365 AA.
AC   P30516;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 47.
DE   Class I histocompatibility antigen, B alpha chain precursor.
OS   Saguinus oedipus (Cotton-top tamarin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Saguinus.
OX   NCBI_TaxID=9490;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=90111120; PubMed=2104912;
RA   Watkins D.I., Letvin N.L., Hughes A.L., Tedder T.F.;
RT   "Molecular cloning of cDNA that encode MHC class I molecules from a
RT   New World primate (Saguinus oedipus). Natural selection acts at
RT   positions that may affect peptide presentation to T cells.";
RL   J. Immunol. 144:1136-1143(1990).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; M33476; AAA36952.1; ALT_INIT; mRNA.
DR   PIR; I72217; I72217.
DR   HSSP; P30504; 1IM9.
DR   SMR; P30516; 25-298.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    365       Class I histocompatibility antigen, B
FT                                alpha chain.
FT                                /FTId=PRO_0000018921.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    365       Cytoplasmic (Potential).
FT   DOMAIN      209    297       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   365 AA;  40999 MW;  B79A9E1FE54C5634 CRC64;
     MTVMAPRTLL LLLSGALVLT ETWAGSHSMR YFSTAVSRPG REEPRYIEVG YVDDTQFVRF
     DSDAASPRME PRAQWVEKEG REYWEEETQR AKAFAQTFRV NLQTALGYYN QSEAGSHTIQ
     MMSGCDLGPD GRLLRGYDQH AYDGKDYISL NEDLRSWTAA DVAAQITQRK WEAANEAERT
     RAYLEGTCVE WLHRYLENGK ETLQRAEPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DMELVETRPT GNGTFQKWAA VVVLSGEEHR YTCHVQHEGL PEPLTLRWEP
     PSQPTIPIMG IVAILAILGA VVTGAVVTAV MWRKKSSDKK GGSYSQAARS DSAQGSDVSL
     TACKV
//
ID   1B02_GORGO              Reviewed;         362 AA.
AC   P30380;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 45.
DE   Class I histocompatibility antigen, GOGO-B0102 alpha chain precursor.
OS   Gorilla gorilla gorilla (Lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92078860; PubMed=1744581; DOI=10.1084/jem.174.6.1491;
RA   Lawlor D.A., Warren E., Taylor P., Parham P.;
RT   "Gorilla class I major histocompatibility complex alleles: comparison
RT   to human and chimpanzee class I.";
RL   J. Exp. Med. 174:1491-1509(1991).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X60693; CAA43101.1; -; mRNA.
DR   PIR; JH0540; JH0540.
DR   HSSP; Q29961; 1HSA.
DR   SMR; P30380; 25-300.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    362       Class I histocompatibility antigen, GOGO-
FT                                B0102 alpha chain.
FT                                /FTId=PRO_0000018902.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    362       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   362 AA;  40205 MW;  E19EEE2B7CC7BECD CRC64;
     MRVTAPRTLL LLLSAALALT ETWAGSHSMR YFDTAVSRPG RGEPRFITVG YVDDTQFVRF
     DSDAASPRME PRAPWIEQEG PEYWDRETQT SKAQAQTDRE NLRIALRYYN QSEAGSHTFQ
     RMFGCDVGPD GRLLRGYSQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL
     RAYLEGTCVE WLRRYLENGR ETLQRADTPK THVTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEER YTCHVQHEGL PKPLTLRWEP
     SSQSTIPIVG IVAGLAVLAV VVIGAVVTAV ICRRKSSGGK GGSYSQAASS DSAQGSDVSL
     TA
//
ID   1B02_PANTR              Reviewed;         362 AA.
AC   P13751; Q9MXK0;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   01-MAY-2007, entry version 53.
DE   CHLA class I histocompatibility antigen, B-2 alpha chain precursor.
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=89030641; PubMed=2460344;
RA   Mayer W.E., Jonker M., Klein D., Ivanyi P., van Seventer G., Klein J.;
RT   "Nucleotide sequences of chimpanzee MHC class I alleles: evidence for
RT   trans-species mode of evolution.";
RL   EMBO J. 7:2765-2774(1988).
RN   [2]
RP   SEQUENCE REVISION.
RA   Mayer W.;
RL   Submitted (FEB-1989) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RX   MEDLINE=20322475; PubMed=10866106; DOI=10.1007/s002510050638;
RA   de Groot N.G., Otting N., Arguello R., Watkins D.I., Doxiadis G.G.,
RA   Madrigal J.A., Bontrop R.E.;
RT   "Major histocompatibility complex class I diversity in a West African
RT   chimpanzee population: implications for HIV research.";
RL   Immunogenetics 51:398-409(2000).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X13116; CAA31508.1; -; mRNA.
DR   EMBL; AF168411; AAF72792.2; -; mRNA.
DR   PIR; S03538; S03538.
DR   HSSP; P30474; 1A9E.
DR   SMR; P13751; 25-300.
DR   KEGG; ptr:450202; -.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    362       CHLA class I histocompatibility antigen,
FT                                B-2 alpha chain.
FT                                /FTId=PRO_0000018917.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    362       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   362 AA;  40488 MW;  FFDB2991044DAA83 CRC64;
     MQVTAPRTVL LLLSAALALT ETWAGSHSMK YFYTAVSRPG RGEPRFISVG YVDDTQFVWF
     DSDAASPREE PRAPWIEQEG PEYWDRETQI SKTNAQTYRE SLRNLRGYYN QSEAGSHIIQ
     RMYGCDMGPD GRLLRGYEQY AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARWAEQL
     RAYLEGTCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
     SSQSTIPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAASS DSAQGSDVSL
     TA
//
ID   1B03_GORGO              Reviewed;         362 AA.
AC   P30381;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 45.
DE   Class I histocompatibility antigen, GOGO-B0103 alpha chain precursor.
OS   Gorilla gorilla gorilla (Lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92078860; PubMed=1744581; DOI=10.1084/jem.174.6.1491;
RA   Lawlor D.A., Warren E., Taylor P., Parham P.;
RT   "Gorilla class I major histocompatibility complex alleles: comparison
RT   to human and chimpanzee class I.";
RL   J. Exp. Med. 174:1491-1509(1991).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X60254; CAA42806.1; -; mRNA.
DR   PIR; JH0541; JH0541.
DR   HSSP; Q29961; 1HSA.
DR   SMR; P30381; 25-300.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; MHC_I_alpha_C.
DR   Gene3D; G3DSA:3.30.500.10; G3DSA:3.30.500.10; 1.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   ProDom; PD000050; MHC_I; 1.
DR   SMART; SM00407; IGc1; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
KW   Glycoprotein; Immune response; Membrane; MHC I; Signal; Transmembrane.
FT   SIGNAL        1     24       By similarity.
FT   CHAIN        25    362       Class I histocompatibility antigen, GOGO-
FT                                B0103 alpha chain.
FT                                /FTId=PRO_0000018903.
FT   TOPO_DOM     25    308       Extracellular (Potential).
FT   TRANSMEM    309    332       Potential.
FT   TOPO_DOM    333    362       Cytoplasmic (Potential).
FT   DOMAIN      209    295       Ig-like C1-type.
FT   REGION       25    114       Alpha-1.
FT   REGION      115    206       Alpha-2.
FT   REGION      207    298       Alpha-3.
FT   REGION      299    308       Connecting peptide.
FT   CARBOHYD    110    110       N-linked (GlcNAc...) (By similarity).
FT   DISULFID    125    188       By similarity.
FT   DISULFID    227    283       By similarity.
SQ   SEQUENCE   362 AA;  40249 MW;  3DEE82572BD81469 CRC64;
     MRVTAPRTLL LLLSAALALT ETWAGSHSMR YFDTAVSRPG RGEPRFITVG YVDDTQFVRF
     DSDAASPRME PRAPWIEQEG PEYWDRETQT SKAQAQTDRE NLRIALRYYN QSEAGSHTIQ
     WMYGCDMGPD GRLLRGYSQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAAREAEQL
     RAYLEGTCVE WLRRYLENGR ETLQRADTPK THVTHHPISD HEATLRCWAL GFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEER YTCHVQHEGL PKPLTLRWEP
     SSQSTIPIVG IVAGLAVLAV VVIGAVVTAV ICRRKSSGGK GGSYSQAASS DSAQGSDVSL
     TA
//
ID   1B04_GORGO              Reviewed;         363 AA.
AC   P30382;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   01-MAY-2007, entry version 47.
DE   Class I histocompatibility antigen, GOGO-B0201 alpha chain precursor.
OS   Gorilla gorilla gorilla (Lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=92078860; PubMed=1744581; DOI=10.1084/jem.174.6.1491;
RA   Lawlor D.A., Warren E., Taylor P., Parham P.;
RT   "Gorilla class I major histocompatibility complex alleles: comparison
RT   to human and chimpanzee class I.";
RL   J. Exp. Med. 174:1491-1509(1991).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC       microglobulin).
CC   -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
DR   EMBL; X60253; CAA42805.1; -; mRNA.
DR   PIR; JH0542; JH0542.
DR   HSSP; P30474; 1A9E.
DR   SMR; P30382; 25-300.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003006; Ig_MHC.
DR   InterPro; IPR001039; MHC_I_alpha_A1A2.
DR   InterPro; IPR010579; M